Evidence map›Paper›PMID 40509132›Full record

ArticleAnimals : an open access journal from MDPI2025

Pharmacokinetic Profile of Two Active Dipyrone Metabolites, 4-Methylaminoantipyrine (MAA) and 4-Aminoantipyrine (AA), Following Intravenous Administration in Dogs: A Preliminary Study.

Andressa N Mouta, Kathryn N Arcoverde, Naftáli S Fernandes, Yanna D B Passos, Caio V A de Oliveira, Robson A Honorato, Gabriel Araujo-Silva, Valéria V de Paula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andressa N MoutaDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.ORCID 0000-0003-0319-2696
Kathryn N ArcoverdeDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.ORCID 0000-0002-5409-7421
Naftáli S FernandesDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.ORCID 0000-0002-8513-1661
Yanna D B PassosDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.ORCID 0009-0006-4497-9830
Caio V A de OliveiraDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.
Robson A HonoratoCentro Universitário INTA-UNINTA, Sobral 62050-100, CE, Brazil.
Gabriel Araujo-SilvaEscola de Química, Universidade do Estado do Amapá, Macapá 68900-070, AP, Brazil.ORCID 0000-0002-9073-1995
Valéria V de PaulaDepartamento de Ciência Animal, Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró 59625-900, RN, Brazil.ORCID 0000-0003-4292-4861

Funding

the National Council for Scientific and Technological Development 403419/2023-9
6 · The paper itself

Abstract

This study aimed to determine the pharmacokinetic profile of the active dipyrone metabolites, 4-methylaminoantipyrine and 4-aminoantipyrine, following intravenous administration in dogs. Eleven mixed-breed dogs received a 25 mg·kg

Indexed as

analgesiachromatographymetabolismmetamizole

Identifiers

PMID40509132
PMCPMC12153896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.