Evidence map›Paper›PMID 40509121›Full record

ArticleAnimals : an open access journal from MDPI2025

The Administration of Heat Shock Protein-70 Bacterial Homolog (DnaK) Improves the Cumulative Survival and the Expression of Immune-Related Genes in Gnotobiotic Full-Sibling Sea Bass Larvae Challenged with

Eva Vallejos-Vidal, Camino Fierro-Castro, María Jesús Santillán-Araneda, Merari Goldstein, Sebastián Reyes-Cerpa, Joan Carles Balasch, Ali Reza Khansari, Kristof Dierckens, Peter Bossier, Lluis Tort and 1 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eva Vallejos-VidalFish Health and Integrative Physiogenomics Research Team, Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170002, Chile.
Camino Fierro-CastroDepartamento de Biología Molecular, Área de Genética, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, 24071 León, Spain.ORCID 0000-0002-5722-7471
María Jesús Santillán-AranedaFish Health and Integrative Physiogenomics Research Team, Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170002, Chile.ORCID 0009-0008-1324-6970
Merari GoldsteinFish Health and Integrative Physiogenomics Research Team, Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170002, Chile.ORCID 0000-0002-7006-964X
Sebastián Reyes-CerpaCentro de Genómica y Bioinformática, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Santiago 8580745, Chile.
Joan Carles BalaschDepartment of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-0771-3746
Ali Reza KhansariDepartment of Biological & Environmental Sciences, University of Gothenburg, 41390 Göteborg, Sweden.
Kristof DierckensLaboratory of Aquaculture & Artemia Reference Center (ARC), Ghent University, Rozier 44, B-9000 Gent, Belgium.
Peter BossierLaboratory of Aquaculture & Artemia Reference Center (ARC), Ghent University, Rozier 44, B-9000 Gent, Belgium.
Lluis TortDepartment of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Felipe E Reyes-LópezFish Health and Integrative Physiogenomics Research Team, Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170002, Chile.ORCID 0000-0002-5001-457X

Funding

Agencia Nacional de Investigación y Desarrollo Fondecyt de iniciacion 11221308Agencia Nacional de Investigación y Desarrollo Fondecyt regular 1252231Aquaexcel EU project 0133/09/14/31Dirección de investigación Científica y tecnológica USACH 082344RL_PostdocDirección de investigación Científica y tecnológica USACH 082541RL_AyudanteMINECO-Spain AGL2016-76069-C2-2-R
6 · The paper itself

Abstract

Heat shock proteins (HSPs), particularly HSP70, play a vital role in fish immune defense against pathogens. The administration of DnaK (bacterial homolog of HSP70) may be a strategy to potentiate the immune response and survival of aquatic organisms. This study evaluates the effect of cells overexpressing DnaK on mortality and immune-related gene expression in gnotobiotic sea bass larvae challenged with

Indexed as

aquacultureDnaKHSP70immune responsesea bass larvaeVibrio anguillarum

Identifiers

PMID40509121
PMCPMC12153677

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.