Evidence map›Paper›PMID 40508999›Full record

ArticleAnimals : an open access journal from MDPI2025

Environmental Risks and Toxicity of Fipronil and Imidacloprid Used in Pets Ectoparasiticides.

Lucia De Marchi, Matteo Oliva, Maria Nobile, Mario Carere, Luca Maria Chiesa, Donatella Degl'Innocenti, Ines Lacchetti, Laura Mancini, Valentina Meucci, Carlo Pretti and 3 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucia De MarchiVeterinary Teaching Hospital, Department of Veterinary Sciences, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0001-6899-4476
Matteo OlivaConsortium for the Interuniversity Center of Marine Biology and Applied Ecology "G. Bacci", 57127 Livorno, Italy.
Maria NobileDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.ORCID 0000-0001-6289-0182
Mario CarereDepartment of Environment and Health, Italian National Institute of Health, 00161 Roma, Italy.ORCID 0000-0002-7611-9353
Luca Maria ChiesaDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.
Donatella Degl'InnocentiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-3342-5537
Ines LacchettiDepartment of Environment and Health, Italian National Institute of Health, 00161 Roma, Italy.ORCID 0000-0003-2554-4269
Laura ManciniDepartment of Environment and Health, Italian National Institute of Health, 00161 Roma, Italy.
Valentina MeucciVeterinary Teaching Hospital, Department of Veterinary Sciences, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0001-5672-7856
Carlo PrettiVeterinary Teaching Hospital, Department of Veterinary Sciences, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0003-4949-2088
Marzia VasarriDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-4241-3992
Roberto Edoardo VillaDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.ORCID 0000-0001-5536-1370
Luigi IntorreVeterinary Teaching Hospital, Department of Veterinary Sciences, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0002-4011-2061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fipronil (FIP) and imidacloprid (IMID) are two of the most commonly used ectoparasiticides to control parasites in pets. Compared with those of farm animals, their environmental risks have generally been considered low because of their limited use; however, the growing pet population and evolving treatment practices make this assumption challenging. To assess these risks, water samples were collected at an animal shelter in Italy to monitor the abundance of ectoparasiticides in aquatic environments. Additionally, laboratory-based ecotoxicological assays were carried out on a range of marine non-target species across different trophic levels (algae, copepods, and mussels). In vitro toxicity tests on human epithelial cell cultures were also implemented to examine potential cytotoxic effects at the levels of human exposure detectable in a domestic setting after pet treatment. Wastewater samples from the shelter contained 0.18 µg L

Indexed as

ecotoxicological assaysectoparasiticidesenvironmental risksfipronilhuman healthimidaclopridpets

Identifiers

PMID40508999
PMCPMC12153832

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.