Evidence map›Paper›PMID 40508766›Full record

ArticlePolymers2025

Antibacterial Crosslinker for Ternary PCL-Reinforced Hydrogels Based on Chitosan, Polyvinyl Alcohol, and Gelatin for Tissue Engineering.

Karina Del Angel-Sánchez, Ana Victoria Treviño-Pacheco, Imperio Anel Perales-Martínez, Oscar Martínez-Romero, Daniel Olvera-Trejo, Alex Elías-Zúñiga

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karina Del Angel-SánchezTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.
Ana Victoria Treviño-PachecoTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.
Imperio Anel Perales-MartínezTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.ORCID 0000-0002-0408-0189
Oscar Martínez-RomeroTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.ORCID 0000-0002-3837-2083
Daniel Olvera-TrejoTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.ORCID 0000-0002-4385-6269
Alex Elías-ZúñigaTecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Ave. Eugenio Garza Sada 2501 Sur, Col. Tecnológico, Monterrey N.L., México City 64700, Mexico.ORCID 0000-0002-5661-2802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current hydrogels used for cartilage tissue engineering often lack the mechanical strength and structural integrity required to mimic native human cartilage. This study addresses this limitation by developing reinforced hydrogels based on a ternary polymer blend of poly(vinyl) alcohol (PVA), gelatin (GL), and chitosan (CH), with gentamicin sulfate (GS) as an antimicrobial agent and a crosslinker. The hydrogels were produced using two crosslinking methods, the freeze/thaw and heated cycles, and reinforced with forcespun polycaprolactone (PCL) nanofiber to improve mechanical performance. Chemical characterization revealed that GS forms weak hydrogen bonds with the ternary polymers, leading to esterification with PVA, and covalent bonds are formed as the result of the free amino group (-NH

Indexed as

articular cartilage replacementforcespinning polycaprolactone fibersgentamicin sulfatehydrogelsnon-Gaussian constitutive material model

Identifiers

PMID40508766
PMCPMC12157165

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.