ReviewPolymers2025
Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors.
Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Cellular and molecular response of dental stem cells to decellularized extracellular matrix scaffolds in regenerative endodontics: a systematic review.Frontiers in dental medicine · 2026Pooled it
- A regenerative strategy for vital pulp therapy: Platelet-rich fibrin augments stem cell viability and pluripotency in bioactive cement environments.Biochemistry and biophysics reports · 2026Article
- Partial radicular versus coronal pulpotomy using chitosan and platelet-rich fibrin in vital permanent molars with irreversible pulpitis, with or without associated apical periodontitis: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Review
- Direct effect of nitrofurantoin on dental pulp stem cell viability and odontoblastic differentiation potential.Journal of conservative dentistry and endodontics · 2026Article
- Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.Cell and tissue banking · 2026Review
- Exosome-mediated Piezo1 activation in 3D-printed titanium scaffolds promotes repair of femoral head osteonecrosis.Journal of nanobiotechnology · 2026Article
- Advances and Challenges in Tissue Engineering: Biomaterials, Cellular Strategies, and Clinical Applications.Journal of functional biomaterials · 2026Review
- Collagen Scaffolds in Regenerative Endodontic Procedures: Current Evidence, Limitations, and Future Perspectives.Polymers · 2026Review
- Bioactive Hydrogels and Scaffolds for Oral Mucosal Regeneration After Oral Squamous Cell Carcinoma Therapy: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2026Review
- Narrative Review of Endodontic Biomaterials.Biomimetics (Basel, Switzerland) · 2026Review
- The Role of Lasers in Enhancing Growth Factor-Mediated Regenerative Endodontic Procedures: A Systematic Review.Cureus · 2026Review
- Regenerative Surgery, State of the Art and New Perspectives: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Bioengineered Teeth and Regenerative Strategies: Advances in Tissue Engineering and Stem Cell Applications.Annals of biomedical engineering · 2026Review
- Antibiotic approaches to endodontic regeneration.Biomaterial investigations in dentistry · 2026Review
- A bioactive composite of freeze-dried stem cells, porous microcarriers, and fibrinogen-thrombin gel for dental pulp tissue engineering.American journal of stem cells · 2026Article
- Gel Delivery Systems in Dental Medicine: From Controlled Release to Regenerative Applications.Gels (Basel, Switzerland) · 2025Review
- Optimizing methods for regenerative endodontics.Regenerative medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative Endodontic Therapies (RETs) offer transformative potential by leveraging polymer-based scaffolds, stem cells, and growth factors to regenerate damaged dental pulp tissue, thereby restoring tooth vitality and prolonging tooth function. While conventional treatments focus on infection control, they often compromise the structural and biological integrity of the tooth. RETs, in contrast, aim to restore the natural function of the pulp-dentin complex by promoting cellular regeneration and immune modulation. In this context, biodegradable polymers-such as collagen, gelatin methacryloyl (GelMA), and synthetic alternatives-serve as scaffolding materials that mimic the extracellular matrix, support cell attachment and proliferation, and enable localized delivery of bioactive factors. Together, the tissue engineering triad-polymer-based scaffolds, stem cells, and signaling molecules-facilitates root development, apical closure, and increased fracture resistance. Recent innovations in polymeric scaffold design, including injectable hydrogels and 3D bioprinting technologies, have enhanced clinical translation by enabling minimally invasive and patient-specific RETs. Despite progress, challenges such as immune compatibility, scaffold degradation rates, and the standardization of clinical protocols remain. RETs, thus, represent a paradigm shift in dental care, aligning with the body's intrinsic healing capacity and offering improved long-term outcomes for patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.