ArticleMaterials (Basel, Switzerland)2025
Covalent Functionalization of Layered Double Hydroxides to Generate Peptide-Based SARS-CoV-2 Nanovaccine.
Alejandra E Liñán-González, Sayma A Rodríguez-Montelongo, Mariano J García-Soto, Daniela Gómez-Zarandona, Susan Farfán-Castro, Gabriela Palestino, Raúl Ocampo-Pérez, Erika Padilla-Ortega, Omar González-Ortega, Sergio Rosales-Mendoza
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In one paragraphArticle in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Alejandra E Liñán-GonzálezCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.
Sayma A Rodríguez-MontelongoCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.ORCID 0000-0003-0186-5754 Mariano J García-SotoCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.ORCID 0000-0001-7635-9309 Daniela Gómez-ZarandonaCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.
Susan Farfán-CastroSección de Biotecnología, Centro de Investigación en Ciencias de la Salud Biomedicina, Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, Lomas 2a Sección, San Luis Potosí 78210, Mexico.ORCID 0000-0002-6934-4966 Gabriela PalestinoCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.ORCID 0000-0002-7535-9363 Raúl Ocampo-PérezCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.
Erika Padilla-OrtegaCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.
Omar González-OrtegaCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.ORCID 0000-0002-5878-8078 Sergio Rosales-MendozaCentro de Investigación y Estudios de Posgrado, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Manuel Nava 6, Zona Universitaria, San Luis Potosí 78210, Mexico.
Funding
Consejo Nacional de Humanidades Ciencias y Tecnologías de México (CONAHCYT) 848290
6 · The paper itselfAbstract
Nanoclays have gained attention in biological applications due to their biocompatibility, low toxicity, and cost-effectiveness. Layered double hydroxides (LDHs) are synthetic nanoclays that have been used as adjuvants and antigen carriers in nanovaccines developed through passive bioconjugation. However, performing active bioconjugation to bind antigens covalently and generate subunit nanovaccines remains unexplored. In this study, we investigated the synthesis, functionalization, and active conjugation of LDH nanoparticles to produce subunit nanovaccines with peptides from SARS-CoV-2. The synthesis of Mg-Al LDHs via a coprecipitation and hydrothermal treatment rendered monodisperse particles averaging 100 nm. Their functionalization with (3-aminopropyl)triethoxysilane was better than it was with other organosilanes. Glutaraldehyde was used as a linker to bind lysine as a model biomolecule to establish the best conditions for reductive amination. Finally, two peptides, P
Indexed as
active conjugationadjuvantlayered double hydroxidesnanoclaysubunit nanovaccine
Identifiers
PMID40508447
PMCPMC12155838
What OpenQuestion holds
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LicenceCC BY
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