Evidence map›Paper›PMID 40508326›Full record

ArticlePlants (Basel, Switzerland)2025

Discovery of Natural Phosphodiesterase 5 Inhibitors from

Ruttanaporn Chantakul, Corine Girard, François Senejoux, Kornkanok Ingkaninan, Nitra Nuengchamnong, Prapapan Temkitthawon

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruttanaporn ChantakulCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0009-0000-4444-7793
Corine GirardUniversité Marie et Louis Pasteur, EFS, INSERM, UMR RIGHT, F-25000 Besançon, France.ORCID 0000-0002-5116-1395
François SenejouxUniversité Marie et Louis Pasteur, EFS, INSERM, UMR RIGHT, F-25000 Besançon, France.ORCID 0000-0002-3643-2804
Kornkanok IngkaninanCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0002-4415-8489
Nitra NuengchamnongScience Laboratory Centre, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0000-0001-5659-9786
Prapapan TemkitthawonCenter of Excellence for Natural Health Product Innovation and Center of Excellence for Innovation in Chemistry, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.ORCID 0009-0008-1640-0988

Funding

Global and Frontier Research University Fund, Naresuan University R2566C053National Research Council of Thailand N41A650401the NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation B16F640099
6 · The paper itself

Abstract

The imbalance of phosphodiesterase 5 (PDE5) enzyme in the male body, or excessive PDE5 enzyme levels, can occur due to factors such as aging, diseases (e.g., cardiovascular disease, diabetes, depressive disorder), and physical behaviors (e.g., alcoholism, smoking, stress). PDE5 is directly associated with erectile dysfunction disease. Currently, many studies aim to find natural PDE5 inhibitors as an alternative to commercial drugs. This study is the first to demonstrate that the ethanolic leaf extract of

Indexed as

at-line LC-QTOF-MS2erectile dysfunctionphosphodiesterase 5rosewood

Identifiers

PMID40508326
PMCPMC12157991

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.