Evidence map›Paper›PMID 40508205›Full record

ArticleInternational journal of molecular sciences2025

Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays.

Saizhen Guo, Ming Zhang, Xingyuan Zhang, Wenjuan Yuan, Chengting Zi, Zemin Xiang, Yongkai Xi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saizhen GuoCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Ming ZhangCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Xingyuan ZhangCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Wenjuan YuanCollege of Science, Yunnan Agricultural University, Kunming 650201, China.
Chengting ZiCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.ORCID 0000-0002-2367-3617
Zemin XiangCollege of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yongkai XiCollege of Science, Yunnan Agricultural University, Kunming 650201, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tetrahydro-β-carboline heterocycle is a privileged scaffold found in numerous natural products and bioactive drugs, demonstrating significant potential for cancer therapy. In this study, we designed and synthesized

Indexed as

Antineoplastic AgentsCarbolinesKinesinsA549 CellsApoptosisCell MovementCell ProliferationHumansLung NeoplasmsMolecular Docking SimulationMolecular Dynamics SimulationAntineoplastic AgentsCarbolinesKIF11 protein, humanKinesinsantitumorEg5 proteinhuman lung adenocarcinoma(A549) cellstetrahydro-β-carboline heterocyclic derivatives

Identifiers

PMID40508205
PMCPMC12154573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.