Evidence map›Paper›PMID 40508188›Full record

ArticleInternational journal of molecular sciences2025

Pelvic Pain Symptoms and Inflammation Among Adolescents and Adults with and Without Endometriosis.

Amy L Shafrir, Ashley Laliberte, Britani Wallace, Allison F Vitonis, Christine B Sieberg, Marzieh Ghiasi, Larry I Magpantay, Marta Epeldegui, Andrew Schrepf, Sawsan As-Sanie and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amy L ShafrirDepartment of Health Sciences and Nutrition, School of Nursing and Health Sciences, Merrimack College, North Andover, MA 01845, USA.
Ashley LaliberteBoston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.
Britani WallaceBoston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.
Allison F VitonisBoston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1243-0844
Christine B SiebergDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1696-0340
Marzieh GhiasiDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0002-9547-7615
Larry I MagpantayUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Marta EpeldeguiUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-7605-5994
Andrew SchrepfDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Sawsan As-SanieDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA.
Kathryn L TerryBoston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.
Stacey A MissmerDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Funding

What is Endometriosis? Deep Phenotyping to Advance Diagnosis and TreatmentR01HD094842 · NICHD · MICHIGAN STATE UNIVERSITY · PI FAZLEABAS, ASGERALLY T., MISSMER, STACEY ANN · 2018 to 2022
$4.2M
Novel biomarkers and pathways of persistent endometriosis-associated pain across the life courseR01HD111242 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sawsan As-Sanie, Kathryn L. Terry · 2023 to 2026
$3.2M
Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediationR21HD096358 · NICHD · MICHIGAN STATE UNIVERSITY · PI MISSMER, STACEY ANN, SHAFRIR, AMY LEE · 2019 to 2020
$499k
J. Willard and Alice S. Marriott Foundation N/ANICHD NIH HHS R01 HD094842NICHD NIH HHS R01 HD111242NICHD NIH HHS R21 HD096358NIH HHS 1R01HD094842-01A1NIH HHS 5R01HD111242-03A1NIH HHS 5R21HD096358-02A1
6 · The paper itself

Abstract

We evaluated inflammatory markers among 389 surgically confirmed endometriosis cases and 505 controls from the Women's Health Study: From Adolescence to Adulthood (A2A) cohort. Participants reported dysmenorrhea, acyclic pelvic pain, dyspareunia, and pain with bowel movements. Using multiplex assays, we measured their levels of plasma interleukin (IL)-1β, -6, -8, -10, and -16, tumor necrosis factor (TNF)-α, monocyte chemotactic protein (MCP)-1 and -4, thymus and activation-regulated chemokine (TARC), and interferon gamma-induced protein (IP)-10. For each symptom, we computed biomarker-level geometric means (GMs) with 95% confidence intervals (95% CI) using multivariate linear regression among the endometriosis cases and controls, with interactions with case/control status tested using Wald statistics. Among the controls, those with dyspareunia had lower levels of IL-8 (GM

Indexed as

EndometriosisInflammationPelvic PainAdolescentAdultBiomarkersCase-Control StudiesCytokinesDyspareuniaFemaleHumansYoung AdultBiomarkersCytokinesbowel painchemokinescytokinesdysmenorrheadyspareuniaendometriosisinflammationpelvic pain

Identifiers

PMID40508188
PMCPMC12156163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.