Evidence map›Paper›PMID 40508180›Full record

ArticleInternational journal of molecular sciences2025

PLAC8 Expression Regulates Trophoblast Invasion and Conversion into an Endothelial Phenotype (eEVT).

Laura J Barragán-Zúñiga, Rodrigo Escalona-Rivano, Catalina Cordero-Tirado, Martha Sosa-Macías, Ivo Carrasco-Wong, Jaime Gutiérrez, Carlos Galaviz-Hernandez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura J Barragán-ZúñigaInstituto Politécnico Nacional, CIIDIR-Durango, Durango 34220, Mexico.ORCID 0000-0002-9925-6668
Rodrigo Escalona-RivanoFaculty of Medicine and Science, Universidad San Sebastián, Santiago 7510602, Chile.ORCID 0009-0008-0439-2263
Catalina Cordero-TiradoFaculty of Medicine and Science, Universidad San Sebastián, Santiago 7510602, Chile.
Martha Sosa-MacíasInstituto Politécnico Nacional, CIIDIR-Durango, Durango 34220, Mexico.
Ivo Carrasco-WongFaculty of Medicine and Science, Universidad San Sebastián, Santiago 7510602, Chile.ORCID 0000-0003-1020-734X
Jaime GutiérrezFaculty of Medicine and Science, Universidad San Sebastián, Santiago 7510602, Chile.
Carlos Galaviz-HernandezInstituto Politécnico Nacional, CIIDIR-Durango, Durango 34220, Mexico.

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 1221362Instituto Politécnico Nacional SIP-20242196 and SIP-20241409
6 · The paper itself

Abstract

PLAC8, expressed by interstitial extravillous trophoblasts (iEVTs), plays a crucial role in trophoblast invasion, differentiation, and immunotolerance. Its dysregulation may contribute to pregnancy complications, such as preeclampsia. This study investigates the role of PLAC8 in trophoblast invasiveness and endothelial-like differentiation under different oxygen tensions. Swan-71 cells were transiently transfected with

Indexed as

Endothelial CellsPregnancy ProteinsTrophoblastsAngiopoietin-2Cell DifferentiationCell LineCell MovementFemaleHumansPhenotypePlacenta Growth FactorPre-EclampsiaPregnancyProteinsVascular Endothelial Growth Factor AAngiopoietin-2PLAC8 protein, humanPlacenta Growth FactorPregnancy ProteinsProteinsVascular Endothelial Growth Factor Aendothelial-like differentiationPLAC8preeclampsiatrophoblast invasion

Identifiers

PMID40508180
PMCPMC12155364

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.