Evidence map›Paper›PMID 40508134›Full record

ArticleInternational journal of molecular sciences2025

Metabolic Imaging of Hyperpolarized [1-

Dirk Mayer, Abubakr Eldirdiri, Amanda L Hrdlick, Boris Piskoun, Joshua C Rogers, Aditya Jhajharia, Minjie Zhu, Julie L Proctor, Ulrich H Leiste, William L Fourney and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0001-7557-9019
Abubakr EldirdiriDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD 21201, USA.
Amanda L HrdlickDepartment of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA.
Boris PiskounDepartment of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA.
Joshua C RogersDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD 21201, USA.
Aditya JhajhariaDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0009-0003-2587-3967
Minjie ZhuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0009-0001-2390-1560
Julie L ProctorDepartment of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA.
Ulrich H LeisteDepartment of Aerospace Engineering, University of Maryland School of Engineering, College Park, MD 20742, USA.
William L FourneyDepartment of Aerospace Engineering, University of Maryland School of Engineering, College Park, MD 20742, USA.
Jody C CantuAir Force Research Laboratory, 711th Human Performance Wing, Air and Space Biosciences Division, En Route Care Section, US Air Force Materiel Command, Baltimore, MD 20723, USA.
Gary FiskumDepartment of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA.
Molly J GoodfellowDepartment of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA.ORCID 0009-0006-1582-352X

Funding

Hyperpolarized 13C metabolic imaging in an endovascular swine model of ischemic strokeR21NS133531 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JANOWSKI, MIROSLAW, MAYER, DIRK · 2023 to 2024
$425k
NIH HHS R21 NS133531NINDS NIH HHS R21 NS133531United States Air Force FA8650-21-2-6L01
6 · The paper itself

Abstract

It is increasingly recognized that early perturbation of energy metabolism might have important implications in management and ultimately the neurological outcome in patients with traumatic brain injury (TBI). At the same time, treatments and screening tools successfully developed in preclinical TBI models have failed to translate to the clinic. As ferrets possess primate-like gyrencephalic brains that may better replicate the human response to neurologic injury, the goal of this study was to noninvasively measure brain energy metabolism after injury in a ferret model of TBI. To this end, metabolic imaging of hyperpolarized (HP) [1-

Indexed as

Brain Injuries, TraumaticPyruvic AcidAnimalsBicarbonatesBrainCarbon IsotopesDisease Models, AnimalEnergy MetabolismFerretsLactic AcidMaleBicarbonatesCarbon-13Carbon IsotopesLactic AcidPyruvic Acidenergy metabolismferrethyperpolarized 13C pyruvatemetabolic imagingtraumatic brain injury

Identifiers

PMID40508134
PMCPMC12154279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.