Evidence map›Paper›PMID 40508101›Full record

ArticleInternational journal of molecular sciences2025

Acute Lymphoblastic Leukemia and Associated HLA-A, B, DRB1, and DQB1 Molecules: A Moroccan Pediatric Case-Control Study.

Khalid Laaziri, Abdelmajid Zyad, El Mehdi Laaziaf, Jamila El Houdzi, Fatimaezzahra Elhanafi, Ikram Brahim, Nadia Lakhouaja, Raja Hazime, Mounia Ammara, Abdellah Naya and 1 more

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khalid LaaziriImmunology and Biodiversity Laboratory, Ain Chock Faculty, Science Hassan II University, Casablanca 20000, Morocco.
Abdelmajid ZyadLaboratory of Agro-Industrial and Medical Biotechnology, Experimental Oncology and Natural Substances Team, Cellular and Molecular Immunopharmacology, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco.ORCID 0000-0002-3997-3649
El Mehdi LaaziafImmunology and Biodiversity Laboratory, Ain Chock Faculty, Science Hassan II University, Casablanca 20000, Morocco.
Jamila El HoudziDepartment of Pediatric Hematology and Oncology, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Fatimaezzahra ElhanafiDepartment of Pediatric Hematology and Oncology, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Ikram BrahimLaboratory of Immunology and HLA, Center of Clinical Research, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Nadia LakhouajaLaboratory of Immunology and HLA, Center of Clinical Research, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Raja HazimeLaboratory of Immunology and HLA, Center of Clinical Research, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Mounia AmmaraImmunology and Biodiversity Laboratory, Ain Chock Faculty, Science Hassan II University, Casablanca 20000, Morocco.ORCID 0009-0007-8702-1590
Abdellah NayaImmunology and Biodiversity Laboratory, Ain Chock Faculty, Science Hassan II University, Casablanca 20000, Morocco.ORCID 0000-0001-6882-5162
Brahim AdmouLaboratory of Immunology and HLA, Center of Clinical Research, Mohammed VI University Hospital, Marrakech 40080, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemia constitutes approximately one-third of all pediatric cancers, with acute lymphoblastic leukemia (ALL) comprising roughly 80% of pediatric leukemia instances. This study sought to ascertain the prevalence of HLA A, B, DR, and DQ allele groups linked with pediatric acute leukemia. We recruited 70 Moroccan children diagnosed with acute lymphoblastic leukemia (ALL), 39 of whom had BCP-ALL and were eligible for hematopoietic stem cell transplantation, compared to a control group of 136 healthy children. Patients and controls were subjected to HLA class I and II typing, utilizing either sequence-specific primers (SSPs) or sequence-specific oligonucleotides (SSOs) in polymerase chain reaction-based techniques. The findings indicated significantly elevated frequencies of HLA-A*68 and B*14 in pediatric patients with ALL relative to the control group (

Indexed as

HLA-A AntigensHLA-B AntigensHLA-DQ beta-ChainsHLA-DRB1 ChainsPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentAllelesCase-Control StudiesChildChild, PreschoolFemaleGene FrequencyGenetic Predisposition to DiseaseHumansInfantMaleHLA-A AntigensHLA-B AntigensHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 Chainsacute lymphoid leukemiachildrenDQB1DRB1HLA-AHLA-BMorocco

Identifiers

PMID40508101
PMCPMC12155374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.