Evidence map›Paper›PMID 40508078›Full record

ArticleInternational journal of molecular sciences2025

Feasibility Assessment of Autologous Human Immune System (HIS) ImmunoGraft Platform Development Using Autologous Mobilized Peripheral Blood (MPB) CD34 Cells Derived from Adult HNSCC Patient.

Bhavna Verma, Georgia Zhuo Chen, Edmund K Waller, Mihir Patel, Allyson Anderson, Neal Goodwin, Amy Wesa, Yong Teng, Nabil F Saba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bhavna VermaChampions Oncology, Inc., Rockville, MD 20850, USA.
Georgia Zhuo ChenWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.ORCID 0000-0002-2572-1926
Edmund K WallerWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.
Mihir PatelWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.
Allyson AndersonWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.
Neal GoodwinChampions Oncology, Inc., Rockville, MD 20850, USA.
Amy WesaChampions Oncology, Inc., Rockville, MD 20850, USA.ORCID 0000-0002-4917-5165
Yong TengWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.ORCID 0000-0002-1856-7289
Nabil F SabaWinship Cancer Institute, Emory University, Atlanta, GA 20850, USA.ORCID 0000-0003-4972-1477

Funding

champions oncology Grant to NFS
6 · The paper itself

Abstract

Humanized mice generated by hematopoietic stem cell (HSC) transplantation are limited by the immune system developed being allogeneic to the tumor. We have innovated a platform to reconstitute an autologous human immune system (HIS) in immunodeficient NOG-EXL mice from mobilized peripheral blood (MPB)-CD34 cells, along with PDX generated from the same patient's tumor tissue. Patients consented under an IRB-approved protocol for tumor biopsy and HSC apheresis at Emory University. HSC collection included mobilization with G-CSF and plerixafor, immunomagnetic bead isolation with CliniMACS, and cryopreservation of CD34

Indexed as

Antigens, CD34Head and Neck NeoplasmsHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationPeripheral Blood Stem CellsSquamous Cell Carcinoma of Head and NeckAdultAnimalsFeasibility StudiesFemaleHumansMaleMiceMiddle AgedTransplantation, AutologousAntigens, CD34autologous stem cellsautologous xenograftimmunograftPDX

Identifiers

PMID40508078
PMCPMC12154748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.