Evidence map›Paper›PMID 40508030›Full record

ArticleInternational journal of molecular sciences2025

Omega-3 Fatty Acid Consumption Alters Uterine Contraction: A Comparative Study on Different Breeds of Rats.

Kalman F Szucs, Dora Vigh, Seyedmohsen Mirdamadi, Reza Samavati, Annamaria Schaffer, Tamara Barna, Tamás Tóth, György Bázár, Henrik Baranyay, Robert Gaspar

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kalman F SzucsDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0002-5878-4691
Dora VighDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Seyedmohsen MirdamadiDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Reza SamavatiDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Annamaria SchafferDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Tamara BarnaDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.
Tamás TóthAgricultural and Food Research Centre, Széchenyi István University, 9026 Győr, Hungary.ORCID 0000-0003-4457-1473
György BázárAdexgo Ltd., 9021 Győr, Hungary.ORCID 0000-0001-9829-4366
Henrik BaranyayUBM Feed Ltd., 2085 Pilisvörösvár, Hungary.
Robert GasparDepartment of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, Hungary.ORCID 0000-0002-1571-7579

Funding

Ministry of Innovation and Technology, Hungary, National Research, Development and Innovation Fund TKP2021-EGA-32National Research, Development, and Innovation Fund of Hungary 2018-1.3.1-VKE-2018-00014
6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) play roles in several physiological and pathophysiological processes, but their effects on reproductive function are controversial. The aim of the study was to investigate the effect of n-3 PUFA-rich fish oil and n-6-rich sunflower oil on sex hormone status, in vivo and in vitro uterine contractility, and endometrial remodeling. Female Sprague Dawley, Lister hooded, and Wistar rats were treated orally for 20 days with 1 mL of tap water, sunflower oil, or fish oil. Blood samples were taken for gonadotropic and sex hormone analysis. In vivo smooth muscle contractions were measured weekly by electromyography. Isolated uterine and cecal contractions were measured after sacrificing the animals. Endometrial remodeling was detected based on the presence of αvβ3 integrin by optical imaging. In Sprague Dawley rats, fish oil increased the LH level and progesterone/estradiol (P4/E2) ratio compared to the sunflower oil-treated group. Uterine contractions were reduced both in vitro and in vivo. Endometrial αvβ3 integrin activity was increased in the fish oil group. In Lister hooded rats, neither sunflower nor fish oil treatments modified the investigated parameters. However, in Wistar rats, both oils increased only the in vivo contractions and reduced the P4/E2 ratio, along with αvβ3 integrin fluorescence. n-3 PUFA-rich fish oil induces a breed-dependent effect on sex hormone status and uterine contractions in rats. The response to PUFA intake may vary significantly within a given species, which may have importance both in animal feeding and human nutrition.

Indexed as

Fatty Acids, Omega-3Uterine ContractionAnimalsEndometriumEstradiolFemaleIntegrin alphaVbeta3ProgesteroneRatsRats, Sprague-DawleyRats, WistarSunflower OilUterusEstradiolFatty Acids, Omega-3Integrin alphaVbeta3ProgesteroneSunflower Oilbreed-dependentcontractilityDHAEPAfatty acidPUFAratsex hormonesmooth muscle electromyographyuterus

Identifiers

PMID40508030
PMCPMC12154105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.