Evidence map›Paper›PMID 40508023›Full record

ArticleInternational journal of molecular sciences2025

Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone-Imidazole Ligands.

Ilya A Shutkov, Nikolai A Melnichuk, Sofya A Ovakimyan, Dmitrii M Mazur, Nataliya E Borisova, Maxim L Kuznetsov, Ivan A Godovikov, Konstantin A Lyssenko, Dmitrii S Yakovlev, Alexander A Spasov and 2 more

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ilya A ShutkovDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.ORCID 0000-0003-0069-8747
Nikolai A MelnichukDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.
Sofya A OvakimyanDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.
Dmitrii M MazurDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.ORCID 0000-0002-9780-1490
Nataliya E BorisovaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.ORCID 0000-0002-0789-5391
Maxim L KuznetsovCentro de Química Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.ORCID 0000-0001-5729-6189
Ivan A GodovikovA.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS), Vavilov Street 28, Building 1, 119991 Moscow, Russia.
Konstantin A LyssenkoDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.ORCID 0000-0002-3500-1287
Dmitrii S YakovlevScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Street 39, 400087 Volgograd, Russia.ORCID 0000-0001-8980-6016
Alexander A SpasovScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Street 39, 400087 Volgograd, Russia.ORCID 0000-0002-7185-4826
Elena R MilaevaDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.
Alexey A NazarovDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, Russia.ORCID 0000-0002-5821-1658

Funding

Fundação para a Ciência e Tecnologia UIDB/00100/2020Fundação para a Ciência e Tecnologia UIDP/00100/2020Russian Science Foundation 22-63-00016Russian Science Foundation 23-73-01076
6 · The paper itself

Abstract

In this study, we synthesized and characterized new imidazole ligands containing pyridone groups, as well as mononuclear and binuclear ruthenium complexes, which are a new class of water-soluble metallacycles. We studied the antiproliferative activity of these compounds in vitro using the MTT assay on a panel of human cancer cell lines and on primary rat fibroblasts, where we observed a complete absence of cytotoxicity up to a concentration of 1000 µM. For the binuclear metallocycle compounds, we investigated their solubility in water, resistance to hydrolysis, and ability to induce apoptosis in tumor cells.

Indexed as

Antineoplastic AgentsCoordination ComplexesImidazolesPyridonesRutheniumAnimalsApoptosisCell Line, TumorCell ProliferationHumansLigandsRatsSolubilityWaterAntineoplastic AgentsCoordination ComplexesimidazoleImidazolesLigandsPyridonesRutheniumWaterantiproliferative activityantitumor compoundscytotoxicitymaltolmetallacyclespyridonesrutheniumwater solubility

Identifiers

PMID40508023
PMCPMC12155346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.