ArticleInternational journal of molecular sciences2025
PBX3-HMGCR Axis Promotes Hepatocellular Carcinoma Progression Through Enhancing De Novo Cholesterol Biosynthesis.
Xia Zhang, Li Qiu, Lei Zhang, Wenfang Li, Debing Xiang, Jian Wang, Shourong Wu, Vivi Kasim
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Xia ZhangKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.
Li QiuKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.
Lei ZhangKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.ORCID 0000-0002-8239-5602 Wenfang LiKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.ORCID 0000-0003-0436-4277 Debing XiangKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.ORCID 0009-0002-4258-2224 Jian WangKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.
Shourong WuKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.ORCID 0000-0001-9650-5465 Vivi KasimKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Department of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing 400044, China.ORCID 0000-0001-9182-8230 Funding
National Natural Science Foundation of China 32270778National Natural Science Foundation of China 82173029the Talent Project of Chongqing University Jiangjin Hospital 2024LJXM005
6 · The paper itselfAbstract
Tumor cells alter lipid metabolic pathways to meet their demands for energy and membrane biosynthesis. Despite its crucial role in tumor cell growth, survival, and metastasis, the mechanisms underlying tumor cell lipid metabolic reprogramming remain poorly understood. Pre-B-cell leukemia transcription factor 3 (PBX3), a member of the PBX family, could promote tumorigenesis; however, whether it is involved in tumor lipid metabolic reprogramming remains unknown. Herein, we found that PBX3 significantly promotes tumor growth by enhancing lipid accumulation in HCC cells. By assessing the effect of PBX3 on the expression levels of lipid metabolism-related genes, we found that PBX3 could positively regulate the expression of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), a rate-limiting enzyme in the cholesterol biosynthesis pathway. Mechanistically, we revealed that PBX3 could directly bind to the -167/-151 region of
Indexed as
Carcinoma, HepatocellularCholesterolHomeodomain ProteinsHydroxymethylglutaryl CoA ReductasesLiver NeoplasmsProto-Oncogene ProteinsAnimalsCell Line, TumorCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansLipid MetabolismMicePromoter Regions, GeneticCholesterolHMGCR protein, humanHomeodomain ProteinsHydroxymethylglutaryl CoA Reductasesproto-oncogene protein Pbx3Proto-Oncogene Proteinscholesterol biosynthesisHMGCRlipid metabolismPBX3tumor metabolic reprogramming
Identifiers
PMID40508020
PMCPMC12154334
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