ReviewInternational journal of molecular sciences2025
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- Picropodophyllotoxin Suppresses Factor Xa Activity, Platelet Aggregation, and Arterial Thrombosis.Biomolecules · 2026Article
- Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities.Nutrients · 2026Review
- From Ethnobotany to Pharmacology: A Comprehensive Review of Selected Asteraceae Species Highlighting Phytochemical Composition, Traditional Uses, and Diverse Pharmacological Activities.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Natural Products as Nutritional Supplements in Human Disease Prevention and Management: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Phytochemical Characterization and Evaluation of Antioxidant, Anti-Inflammatory, Cytotoxic, Genotoxic, and Anti-Arthritic Activities ofPlants (Basel, Switzerland) · 2026Article
- Boiogito Ameliorates Inflammation-Associated Adipocyte Dysfunction and Restores Adipogenesis in Association with Suppression of NF-κB Signaling.Current issues in molecular biology · 2026Article
- Review
- Article
- Plant-Derived Peptide-Polymer Therapeutics for Cutaneous Infections and Inflammation: Mechanistic Basis, Delivery Design and Translational Considerations.Pharmaceutics · 2026Review
- Pistacia atlantica subsp. mutica essencial oil enhances proliferation and telomerase activity in senescent mesenchymal stem cells.BMC complementary medicine and therapies · 2026Article
- Advances in Eco-Friendly Extraction of Fruit Bioactive Compounds: Technologies, Challenges and Future Directions.Analytical science advances · 2026Review
- COMolecules (Basel, Switzerland) · 2026Article
- In Vitro Anti-Inflammatory Activity and Molecular Docking Analysis of Compounds Isolated fromCurrent issues in molecular biology · 2026Article
- Hippocampal Lipocalin-2 in T2DM Associated Neurodegeneration: A Therapeutic Perspective.Neurochemical research · 2026Review
- Combined Anti-Inflammatory Effects of Curcumin and Evodiamine: In Vitro Synergy, Docking, and Molecular Orbital Insights.International journal of molecular sciences · 2026Article
- Eriodictyol in Cancer Therapy: Reviewing Mechanistic Insights and Translational Opportunities.International journal of molecular sciences · 2026Review
- Anti-Inflammatory Activity ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Chemical Composition, Enantioselective Profile, and Preliminary Screening of Biological Activities of the Essential Oil from Aerial Parts fromPlants (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Chronic inflammation is a key contributor to the development and progression of numerous chronic diseases, including cardiovascular diseases, type 2 diabetes, neurodegenerative disorders, cancer, and obesity. As the side effects of conventional anti-inflammatory drugs pose challenges, plant-derived compounds have emerged as promising alternatives due to their potent anti-inflammatory properties and minimal adverse effects. This review explores the molecular mechanisms by which these compounds alleviate chronic inflammation and highlights their potential role in disease prevention. Polyphenols (e.g., quercetin and resveratrol), flavonoids (e.g., luteolin and apigenin), carotenoids (e.g., β-carotene and lycopene), and other phytochemicals (e.g., curcumin and gingerol) modulate inflammatory pathways, such as nuclear factor-κB and mitogen-activated protein kinase, reduce oxidative stress, and inhibit pro-inflammatory cytokines. Plant-derived compounds interact with the gut microbiota, enhancing anti-inflammatory effects. Evidence from animal studies and clinical trials has demonstrated their efficacy in reducing inflammation-related biomarkers and improving health outcomes. However, challenges such as low bioavailability and determination of the optimal dosage require further investigation. Advancing delivery technologies and personalized nutrition strategies may help overcome these barriers. This review emphasizes the therapeutic potential of plant-derived compounds in preventing chronic diseases and underscores the need for continued research to translate these findings into practical applications for public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.