Evidence map›Paper›PMID 40508012›Full record

ReviewInternational journal of molecular sciences2025

Advances in Research on the B-Lineage Transcription Factor EBF1 in Solid Tumors.

Qinghua Li, Yanchuan Zhang, Guojing Xie, Junhao Cui, Ping Leng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qinghua LiChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Sichuan Key Laboratory of Medical Molecular Testing, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yanchuan ZhangChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Sichuan Key Laboratory of Medical Molecular Testing, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Guojing XieChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Sichuan Key Laboratory of Medical Molecular Testing, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Junhao CuiChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Sichuan Key Laboratory of Medical Molecular Testing, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Ping LengChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Sichuan Key Laboratory of Medical Molecular Testing, College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early B-cell factor 1 (EBF1) is a crucial transcription factor that governs the development and differentiation of B lymphocytes. Furthermore, it is essential in developing multiple organs and tissues. The functional dysregulation of EBF1 expression is intricately associated with the occurrence, recurrence, and treatment resistance of B-lineage acute lymphoblastic leukemia. In recent years, EBF1 has demonstrated a more intricate and multifaceted role in solid tumors. It does not immutably adhere to the conventional classification of tumor suppressor genes. On the contrary, EBF1 is a flexible regulatory factor that exhibits diverse functional characteristics and regulatory models according to the different types of tumors and their microenvironment differences. This review elucidates the unique function of EBF1 in various solid tumors and associated signaling pathways, offering a theoretical foundation for a thorough comprehension of EBF1's intricate roles in solid tumor development.

Indexed as

B-LymphocytesNeoplasmsTrans-ActivatorsAnimalsGene Expression Regulation, NeoplasticHumansSignal TransductionTumor MicroenvironmentEBF1 protein, humanTrans-ActivatorsEBF1oncogenesignaling pathwaysolid tumortumor suppressor gene

Identifiers

PMID40508012
PMCPMC12154365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.