Evidence map›Paper›PMID 40508009›Full record

ArticleInternational journal of molecular sciences2025

Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells.

Maksym Skrypnyk, Tetiana Yatsenko, Oleksandra Riabets, Olga Zuieva, Iryna Rodionova, Margarita Skikevych, Yousef Salama, Taro Osada, Morikuni Tobita, Satoshi Takahashi and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maksym SkrypnykJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0002-9552-4098
Tetiana YatsenkoJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0001-8601-1939
Oleksandra RiabetsJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Olga ZuievaJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Iryna RodionovaJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Margarita SkikevychDepartment of Surgical Dentistry and Maxillofacial Surgery with Plastic and Reconstructive Surgery of Head and Neck, Poltava State Medical University, 23 Shevchenko Street, 36011 Poltava, Ukraine.ORCID 0000-0002-4401-2703
Yousef SalamaAn-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 99900800, Palestine.ORCID 0000-0001-6254-6381
Taro OsadaDepartment of Gastroenterology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-shi, Chiba 279-0021, Japan.
Morikuni TobitaDepartment of Oral and Maxillofacial Surgery, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0001-7422-1920
Satoshi TakahashiDivision of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, 4 Chome-6-1, Minato-Ku, Tokyo 108-8639, Japan.
Nobutaka HattoriCenter for Genome and Regenerative Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0002-2034-2556
Kazuhisa TakahashiJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0001-5749-4118
Koichi HattoriCenter for Genome and Regenerative Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.
Beate HeissigJuntendo Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan.ORCID 0000-0002-0348-5934

Funding

Grant from the Society of Iodine ScienceHeiwa Nakajima FoundationInstitute for Environmental & Gender-specific Medicine, Juntendo UniversityInternational Joint Usage/Research Center, the Institute of Medical Science, the University of Tokyointramural funding (MT)Japan Society for the Promotion of Science JP18K08657Japan Society for the Promotion of Science JP21K08404Japan Society for the Promotion of Science JP21K08692Japan Society for the Promotion of Science JP22F21773Japan Society for the Promotion of Science JP22K07206Japan Society for the Promotion of Science JP22KF0337Japan Society for the Promotion of Science JP24K10435Japan Society for the Promotion of Science JP24K11549Okinaka Memorial Institute for Medical ResearchRadiation effects associationTaiju Life Social Welfare FoundationTerumo (Japan)The Japanese Society of Hematology Research Grant
6 · The paper itself

Abstract

Salivary gland cancers (SGCs) pose a therapeutic challenge due to their aggressive nature and limited treatment options. Ion transporters, particularly the sodium/iodide symporter (SLC5A5), which transport iodine in the form of iodide anion (I

Indexed as

ApoptosisPotassium IodideSalivary Gland NeoplasmsAnimalsCell Line, TumorCell ProliferationCell SurvivalErbB ReceptorsHumansMiceReactive Oxygen SpeciesSignal TransductionSodium-Iodide SymportersSymportersErbB ReceptorsPotassium IodideReactive Oxygen SpeciesSodium-Iodide SymportersSymportersapoptosisBAXcaspasescell proliferationepidermal growth factorhead and neck canceriodidespotassium iodidereactive oxygen speciessalivary gland neoplasmssodium–iodide symporter

Identifiers

PMID40508009
PMCPMC12155144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.