Evidence map›Paper›PMID 40508008›Full record

ArticleInternational journal of molecular sciences2025

Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia.

Baukje Brattinga, Honglei Huang, Sergei Maslau, Adam M Thorne, James Hunter, Simon Knight, Michel M R F Struys, Henri G D Leuvenink, Geertruida H de Bock, Rutger J Ploeg and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Baukje BrattingaDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-9219-9317
Honglei HuangNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.
Sergei MaslauNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.
Adam M ThorneNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.
James HunterNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.ORCID 0000-0002-4972-6879
Simon KnightNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.ORCID 0000-0003-4837-9446
Michel M R F StruysDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-0421-536X
Henri G D LeuveninkDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Geertruida H de BockDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-3104-4471
Rutger J PloegNuffield Department of Surgical Sciences, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7FZ, UK.ORCID 0000-0001-7801-665X
Benedikt M KesslerTarget Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX1 2JD, UK.ORCID 0000-0002-8160-2446
Gertrude J Nieuwenhuijs-MoekeDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-9874-2632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical trauma elicits a complex inflammatory stress response, contributing to postoperative morbidity and recovery variability. This response is influenced by patient-specific factors and surgical and anesthetic techniques. To isolate the impact of anesthesia on the acute phase response, we investigated plasma proteomic changes in a uniquely homogeneous cohort of healthy, living kidney donors (

Indexed as

Acute-Phase ReactionLaparoscopyLiving DonorsNephrectomyPropofolSevofluraneAdultBiomarkersFemaleHumansKidneyKidney TransplantationMaleMiddle AgedProteomicsBiomarkersPropofolSevofluraneanesthesialaparoscopic surgeryliving kidney donorspropofolsevofluranesurgical stress response

Identifiers

PMID40508008
PMCPMC12154559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.