Evidence map›Paper›PMID 40507942›Full record

ArticleInternational journal of molecular sciences2025

SPINT1 Expressed in Epithelial Cells of Choroid Plexus in Human and Mouse Brains.

Ryuta Murakami, Yoichi Chiba, Genta Takebayashi, Keiji Wakamatsu, Yumi Miyai, Koichi Matsumoto, Naoya Uemura, Ken Yanase, Yuichi Ogino, Masaki Ueno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryuta MurakamiDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Yoichi ChibaDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Genta TakebayashiDepartment of Anesthesiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Keiji WakamatsuDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Yumi MiyaiDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Koichi MatsumotoDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Naoya UemuraDepartment of Anesthesiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Ken YanaseDepartment of Anesthesiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.
Yuichi OginoDepartment of Anesthesiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.ORCID 0000-0001-6508-7547
Masaki UenoDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan.ORCID 0000-0002-6592-3573

Funding

Japan Society for the Promotion of Science 23K10827Japan Society for the Promotion of Science 24K10554Japan Society for the Promotion of Science 24K17847
6 · The paper itself

Abstract

The functional significance of the choroid plexus (CP), such as in the control of circadian rhythm as well as production of cerebrospinal fluid, is attracting attention. Transepithelial and junctional transport between epithelial cells of CP plays an important role in its function. Recently, an epithelial cadherin, E-cadherin, as well as non-epithelial cadherins were confirmed to be expressed in CP epithelial cells. The serine protease inhibitor Kunitz type 1 (SPINT1) is expressed in many kinds of epithelial cells and affects epithelial developmental function by controlling E-cadherin expression. However, it has not been confirmed whether SPINT1 is expressed in epithelial cells of CP. Thus, in this study, we examined whether SPINT1 is expressed in CP epithelial cells by immunohistochemistry and RT-PCR. Immunohistochemical expression of SPINT1 was noted in the cytoplasm of epithelial cells of humans and mice, and mRNA of SPINT1 was expressed in samples derived from the CP of mice. SPINT1 was typically expressed in CP epithelial cells with E-cadherin and Smad-interacting protein (SIP1), an E-cadherin transcriptional repressor. Some enlarged epithelial cells showed strong SPINT1 signals. These findings indicate that SPINT1 is expressed in epithelial cells of CP in relation to E-cadherin expression.

Indexed as

BrainChoroid PlexusEpithelial CellsAnimalsCadherinsFemaleHumansMaleMiceMice, Inbred C57BLRNA, MessengerCadherinsRNA, Messengerchoroid plexusE-cadherinepithelial cellsSIP1SPINT1

Identifiers

PMID40507942
PMCPMC12155093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.