Protective Effect of a Hexapeptide Derived from Rotifer-Specific SCO-Spondin Against Beta-Amyloid Toxicity.

Zsolt Datki, Rita Sinka, Brian J Dingmann, Bence Galik, Antal Szabo, Zita Galik-Olah, Gabor K Toth, Zsolt Bozso

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zsolt DatkiMicro-In Vivo Biomolecule Research Laboratory, Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation of the University of Szeged, Dugonics ter 13, 6720 Szeged, Hungary.ORCID 0000-0002-2537-4741

Rita SinkaDepartment of Genetics, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, 6726 Szeged, Hungary.ORCID 0000-0003-4040-4184

Brian J DingmannDepartment of Math Science and Technology, University of Minnesota Crookston, 2900 University Avenue, Crookston, MN 56716, USA.ORCID 0000-0002-1212-9245

Bence GalikSzentagothai Research Center, Genomic and Bioinformatic Core Facility, 7622 Pecs, Hungary.ORCID 0000-0002-3949-7005

Antal SzaboMicro-In Vivo Biomolecule Research Laboratory, Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation of the University of Szeged, Dugonics ter 13, 6720 Szeged, Hungary.

Zita Galik-OlahiBioScience Ltd., 7625 Pécs, Hungary.

Gabor K TothDepartment of Medical Chemistry, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, 6725 Szeged, Hungary.

Zsolt BozsoDepartment of Medical Chemistry, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, 6725 Szeged, Hungary.ORCID 0000-0002-5713-3096

Funding

János Bolyai Research Scholarship of the Hungarian Academy of Sciences 2021TKP2021-EGA-32 of the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme TKP2021-EGA-32Translational Biomedicine Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation of the University of Szeged 2024

6 · The paper itself

Abstract

The Rotimer (rotifer-specific biopolymer) like SCO-spondin (R-SSPO/1), predicted as the main component of this biopolymer, is an adequate base for the design of functional small peptides. This macromolecule is interactive and protective against neurotoxic human-type beta-amyloid 1-42 aggregates (agg-Aβ). The current work presents biological investigations and predictable molecular interaction analysis of DSSNDL and PNCRDGSDE peptides that were synthesized based on the sequences of R-SSPO/1. Viability assays (NADH-dependent cellular reduction capacity, intracellular esterase activity, and motility) were performed on differentiated neuro-type cell cultures (SH-SY5Y and PC12) and on Rotimer-depleted rotifers (

Indexed as

Amyloid beta-PeptidesNeuroprotective AgentsOligopeptidesPeptide FragmentsRotiferaAnimalsCell SurvivalHumansMicePC12 CellsRatsAmyloid beta-PeptidesNeuroprotective AgentsOligopeptidesPeptide Fragmentsbeta-amyloidbiopolymerrotiferSCO-spondin

Identifiers

PMID40507923

DOI10.3390/ijms26115109

PMCPMC12154537

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.