Evidence map›Paper›PMID 40507859›Full record

ArticleInternational journal of molecular sciences2025

Ergolide Regulates Microglial Activation and Inflammatory-Mediated Dysfunction: A Role for the Cysteinyl Leukotriene Pathway.

Danielle M Galvin, Sara Fernandez-Garcia, Emma Dawson, Ciara Pryce, Billy P Egan, Niamh C Clarke, Alison L Reynolds, Derek A Costello

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danielle M GalvinUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-6281-3360
Sara Fernandez-GarciaUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.
Emma DawsonUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.
Ciara PryceUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.
Billy P EganUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0009-0009-6220-2007
Niamh C ClarkeUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0009-0007-5022-2890
Alison L ReynoldsUCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-3147-0094
Derek A CostelloUCD School of Biomolecular & Biomedical Science, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-5449-6166

Funding

Horizon 2020 Marie Skłodowska-Curie Actions research and innovation programme 101007931UCD STEM Challenge Fund R25134
6 · The paper itself

Abstract

Neurodegenerative diseases are characterised by the progressive loss of neurons, leading to a decline in specific brain functions. Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent, affecting approximately 60 million people worldwide. The pathogenesis of these diseases is complex, combining inflammatory, oxidative, and excitotoxic processes that result in neuronal dysfunction and death. Despite recent advances, there is currently no cure for AD and PD. Available therapies demonstrate limited efficacy, highlighting the continuing need for novel therapeutic approaches. Ergolide, a naturally occurring sesquiterpene lactone from the

Indexed as

CysteineInflammationLactonesLeukotrienesMicrogliaSesquiterpenesAnimalsCytokinesDisease Models, AnimalHumansNF-kappa BNitric OxideSignal TransductionZebrafishCysteineCytokinesLactonesLeukotrienesNF-kappa BNitric OxideSesquiterpenescytokinesmicrogliaNFκBnitric oxideTLRzebrafish larvae

Identifiers

PMID40507859
PMCPMC12154084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.