Evidence map›Paper›PMID 40507839›Full record

ArticleInternational journal of molecular sciences2025

Lifetime Variations of Prolactin Receptor Isoforms mRNA in the Hippocampus and Dentate Gyrus of the Rat-Effects of Aging.

Marta Carretero-Hernández, Elisa Herráez, David Hernández-González, David Díez-Castro, Leonardo Catalano-Iniesta, Josefa García-Barrado, Enrique J Blanco, José Carretero

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marta Carretero-HernándezDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0712-2804
Elisa HerráezDepartment of Physiology and Pharmacology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-9271-3320
David Hernández-GonzálezDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0443-1978
David Díez-CastroDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0474-3672
Leonardo Catalano-IniestaDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1957-1762
Josefa García-BarradoLaboratory of Neuroendocrinology, Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-2552-5973
Enrique J BlancoDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-5332-4282
José CarreteroDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.

Funding

Junta de Castilla y León CODE 2018/00221/001
6 · The paper itself

Abstract

Prolactin is a hormone for which actions on the central nervous system such as neurogenesis and neuroprotection have been described by acting on specific receptors. The presence of prolactin receptors in the brain, including the hippocampus, is well documented; however, it is unknown whether these receptors change with age and whether they are related to sex. For this reason, a study of the expression of prolactin receptors, in the short and long isoforms, in the hippocampus of male and female rats has been carried out by qPCR and in situ hybridization, with a densitometric analysis in the following life stages: prepubertal, postpubertal, young adult, adult, and old. The results revealed the greater expression of the long isoform than of the short isoform in males, but not in females, with significant differences between males and females and in the different life stages studied. With significant differences, the highest expression of both isoforms appeared in male rats in the postpubertal stage, and the lowest expression was observed in adult and old animals. In situ hybridization showed differences in the localization of PRLR mRNA expression in CA1, CA3, and DG depending on the age and sex of the rats. The results obtained suggest that hippocampal aging is related to a decrease in prolactin receptors, which helps to better understand brain aging.

Indexed as

AgingDentate GyrusHippocampusReceptors, ProlactinRNA, MessengerAnimalsFemaleMaleProtein IsoformsRatsRats, WistarProtein IsoformsReceptors, ProlactinRNA, Messengeraginghippocampuslarge prolactin receptorshort prolactin receptor

Identifiers

PMID40507839
PMCPMC12155476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.