Evidence map›Paper›PMID 40507833›Full record

ReviewInternational journal of molecular sciences2025

Skin Microbiome and Radiation-Induced Skin Injury: Unraveling the Relationship, Mechanisms, and Therapeutic Implications.

Aleksandra Wiktoria Bratborska, Paweł Głuszak, Maria Joks, Joanna Kaźmierska, Jakub Pazdrowski, Adriana Polańska, Shalini Jain, Hariom Yadav, Michal M Masternak, Aleksandra Dańczak-Pazdrowska

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandra Wiktoria BratborskaDepartment of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0009-0006-5288-1577
Paweł GłuszakDoctoral School, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0002-5877-491X
Maria JoksDepartment of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0009-0005-9892-6673
Joanna KaźmierskaDepartment of Radiotherapy, Poznan University of Medical Sciences, 61-866 Poznan, Poland.
Jakub PazdrowskiDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland.
Adriana PolańskaDepartment of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.ORCID 0000-0003-4504-1597
Michal M MasternakDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, 61-866 Poznan, Poland.
Aleksandra Dańczak-PazdrowskaDepartment of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy (RT) is a treatment method commonly used in oncology. A vast majority of patients undergoing RT suffer from radiation-induced skin injury (RISI), which results from complex biochemical reactions in the irradiated skin. Current strategies for preventing and managing RISI are insufficient for achieving full skin regeneration. Multiple studies have shown that alterations in the skin microbiome correlate with the development and severity of RISI. These studies suggest that dysbiosis is a crucial factor in promoting radiation-associated dermatitis. Targeting the skin microbiota presents a potential therapeutic approach that could significantly improve the quality of life for patients undergoing RT. This review aims to present current findings on the interplay between the skin microbiome and radiation-induced skin damage as well as to discuss potential therapeutic strategies for preventing and mitigating this condition.

Indexed as

MicrobiotaRadiation InjuriesRadiodermatitisSkinAnimalsDysbiosisHumansRadiotherapySkin Microbiomecancerinjurymicrobiomeradiationskin

Identifiers

PMID40507833
PMCPMC12155174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.