Evidence map›Paper›PMID 40507816›Full record

ArticleInternational journal of molecular sciences2025

The MDA-MB-231 Breast Cancer Cell Secretomes Modify Metabolomes of

Majdoleen AlDawsari, Mysoon M Al-Ansari, Reem H AlMalki, Anas M Abdel Rahman, Monther Al-Alwan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Majdoleen AlDawsariDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Mysoon M Al-AnsariDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2501-691X
Reem H AlMalkiMetabolomics Section, Precision Medicine Laboratory Department, Genomics Medicine Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Anas M Abdel RahmanMetabolomics Section, Precision Medicine Laboratory Department, Genomics Medicine Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-9527-9424
Monther Al-AlwanCell Therapy and Immunobiology Department, Research and Innovation, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0003-2150-5297

Funding

King Faisal Specialist Hospital & Research Centre RAC#2240005 and 2220015
6 · The paper itself

Abstract

Breast cancer (BC) is globally becoming a great challenge, being both the most diagnosed cancer and the leading cause of death in women. In addition to cancer cells, many bacteria co-inhabit BC, which differ in type and number from the resident microbiota found in healthy breast tissue. While many reports have demonstrated the ability of different bacteria to dysregulate BC's metabolites, the reciprocal effect of these metabolites on the bacterial microbiota has not yet been investigated. Herein, we assess the effect of conditioned media (CM) from a triple-negative BC cell line (MDA-MB-231) on the metabolic profile of

Indexed as

BreastBreast NeoplasmsMetabolomeMicrobiotaPseudomonas aeruginosaCell Line, TumorCulture Media, ConditionedFemaleHumansCulture Media, Conditionedbreast cancermetabolic pathwaysmicrobiomeuntargeted metabolomics

Identifiers

PMID40507816
PMCPMC12155445

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.