Evidence map›Paper›PMID 40507798›Full record

ArticleInternational journal of molecular sciences2025

The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer.

Ho Tsoi, Chan-Ping You, Koei Ho-Lam Cheung, Yin-Suen Tse, Ui-Soon Khoo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ho TsoiDepartment of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-2037-9575
Chan-Ping YouDepartment of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Koei Ho-Lam CheungDepartment of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yin-Suen TseDepartment of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ui-Soon KhooDepartment of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-2200-7505

Funding

General Research Fund 17106824the Committee on Research and Conference Grants from the University of Hong Kong 202010160029the Committee on Research and Conference Grants from the University of Hong Kong 202111160035the Committee on Research and Conference Grants from the University of Hong Kong 2302101666the Committee on Research and Conference Grants from the University of Hong Kong 2303101663
6 · The paper itself

Abstract

BQ323636.1 (BQ), a splice variant of NCOR2, is associated with endocrine therapy resistance and poorer prognosis in ER-positive breast cancer. This study investigates the role of BQ in modulating lipid metabolism to support tumor growth. RNA sequencing of BQ-overexpressing breast cancer cells revealed significant enrichment of fatty acid metabolism pathways (hsa01212 and hsa00061;

Indexed as

Acetate-CoA LigaseBreast NeoplasmsCoenzyme A LigasesFatty AcidsNuclear Receptor Co-Repressor 2AnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLipid MetabolismLong-Chain-Fatty-Acid-CoA LigaseMCF-7 CellsMiceMice, NudeAcetate-CoA LigaseCoenzyme A LigasesFatty AcidsLong-Chain-Fatty-Acid-CoA LigaseNCOR2 protein, humanNuclear Receptor Co-Repressor 2PPAR gammaACSL4BQ323636.1breast cancerlipid metabolism

Identifiers

PMID40507798
PMCPMC12154026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.