Evidence map›Paper›PMID 40507794›Full record

ArticleInternational journal of molecular sciences2025

Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of the

Chang-Han Ho, Cheng-Yu Tsai, Chi-Chieh Chang, Chin-Ju Hu, Cheng-Yen Huang, Ying-Chang Lu, Pei-Hsuan Lin, Chin-Hsien Lin, Han-I Lin, Chih-Hsin OuYang and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chang-Han HoDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0009-0007-3299-6657
Cheng-Yu TsaiDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0001-6150-4577
Chi-Chieh ChangDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0002-0783-2868
Chin-Ju HuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0002-3170-9691
Cheng-Yen HuangGene Knockout/in Cell Line Modeling Core, Human Disease Modeling Center, First Core Laboratory, Branch Office of Research and Development, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
Ying-Chang LuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.
Pei-Hsuan LinDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.
Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, Taipei 100225, Taiwan.
Han-I LinDepartment of Neurology, National Taiwan University Hospital, Taipei 100225, Taiwan.
Chih-Hsin OuYangDepartment of Neurology, National Taiwan University Hospital, Taipei 100225, Taiwan.
Chuan-Jen HsuDepartment of Otolaryngology-Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, Taiwan.ORCID 0000-0002-7548-7736
Tien-Chen LiuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0001-6771-5025
You-Tzung ChenGraduate Institute of Medical Genomics and Proteomics, National Taiwan University College of Medicine, Taipei 100233, Taiwan.ORCID 0000-0001-6510-3420
Yen-Hui ChanDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.
Yen-Fu ChengDepartment of Medical Research, Taipei Veterans General Hospital, Taipei 112201, Taiwan.ORCID 0000-0003-1995-5854
Chen-Chi WuDepartment of Otolaryngology-Head and Neck Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan.ORCID 0000-0002-5047-2204

Funding

National Science and Technology Council of Taiwan 107-2622-B-002-008-CC2National Taiwan University Hospital 106-T04
6 · The paper itself

Abstract

Recessive variants of

Indexed as

CRISPR-Cas SystemsGene EditingHearing Loss, SensorineuralMembrane Transport ProteinsSulfate TransportersGoiter, NodularHumansMembrane Transport ProteinsSLC26A4 protein, humanSulfate TransportersCRISPR/Cas9gene editinghearing losshomology-independent targeted integrationPendred syndromeSLC26A4

Identifiers

PMID40507794
PMCPMC12155412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.