Evidence map›Paper›PMID 40507475›Full record

ReviewJournal of clinical medicine2025

Long-Term Antithrombotic Therapy in Patients with Atrial Fibrillation and Percutaneous Coronary Intervention.

Antonio Capolongo, Vincenzo De Sio, Felice Gragnano, Mattia Galli, Natale Guarnaccia, Pasquale Maddaluna, Giuseppe Verde, Vincenzo Acerbo, Pierre Sabouret, Daniele Giacoppo and 8 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Antonio CapolongoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Vincenzo De SioDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0009-0001-1609-4684
Felice GragnanoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-6943-278X
Mattia GalliDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-3909-182X
Natale GuarnacciaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Pasquale MaddalunaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giuseppe VerdeDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Vincenzo AcerboDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Pierre SabouretHeart Institute, Cardiology Department, Pitié-Salpétrère Hospital, Sorbonne University, 75005 Paris, France.
Daniele GiacoppoDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico-San Marco", University of Catania, 95124 Catania, Italy.ORCID 0000-0001-9008-3011
Matteo ConteDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-9932-224X
Silvio ColettaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Vincenzo DianaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Michelangelo LucianiDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Elisabetta MoscarellaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Arturo CesaroDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0003-4435-1235
Francesco PellicciaDepartment of Cardiovascular Sciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-1260-1308
Paolo CalabròDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-5018-830X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal long-term antithrombotic treatment of patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) remains controversial. Current guidelines recommend a short initial period of triple antithrombotic therapy (e.g., 1 week), followed by dual therapy consisting of an oral anticoagulation agent and a single antiplatelet agent for 6 months in patients undergoing elective PCI and 12 months in patients with acute coronary syndromes. After this course of combination therapy, anticoagulation monotherapy is recommended. In daily practice, however, the optimal strategy for long-term antithrombotic therapy remains debated. A growing body of evidence supports the safety and efficacy of oral anticoagulation monotherapy, but its use in clinical practice remains inconsistent. This review aims to evaluate the available evidence on chronic antithrombotic regimens in patients with AF undergoing PCI, with a focus on key clinical considerations, such as the selection of optimal long-term therapy that balances ischemic and bleeding risks. It also highlights that, despite robust supporting evidence, significant gaps persist in real-world implementation.

Indexed as

antithrombotic therapyatrial fibrillationbleedingP2Y12 inhibitorsPCI

Identifiers

PMID40507475
PMCPMC12155727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.