ReviewJournal of clinical medicine2025
Perioperative Nutritional and Metabolic Factors Affecting Surgical Outcomes in Head and Neck Cancer Free Flap Reconstruction: A Comprehensive Review.
Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Elevated BMI Is Not Associated With Adverse Outcomes in Open Airway Reconstruction.The Laryngoscope · 2026Article
- Clinical risk factors associated with postoperative malnutrition in patients with laryngeal cancer: A retrospective study.Medicine · 2026Article
- "Beyond the scale: body mass index as a hidden player in post-extraction complications".BMC oral health · 2026Observational
- Feeding tube dependence and postoperative complications in older adults after head and neck cancer surgery: a retrospective cohort study.BMC geriatrics · 2026Article
- Risk stratification of postoperative enteral feeding intolerance using explainable machine learning in oral cancer free flap reconstruction.Frontiers in nutrition · 2026Article
- Validation of the Controlling Nutritional Status (CONUT) Score and the Systemic Immune-Inflammation Index (SII) for Predicting Leakage and Surgical Complications After Head and Neck Free Flap Reconstruction: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Human papillomavirus prevalence, genotype distribution, risk factors, and cervical pathology association in women aged 50 years and older: a retrospective cross-sectional study in Xinjiang, China.Frontiers in oncology · 2025Article
- Multimodal analgesia in resource-limited settings: A comparative analysis of postoperative pain management strategies in Pakistan.PLOS global public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck cancer (HNC) remains a major global health issue. It is closely linked to smoking, alcohol use, and HPV infection. Nutritional and metabolic factors significantly influence surgical outcomes in these patients, especially when undergoing extensive resections and microsurgical free flap reconstruction. This comprehensive review aims to evaluate how perioperative nutritional status-particularly body mass index (BMI), serum albumin and prealbumin levels, and enteral vs. oral feeding strategies-affects complication rates, wound healing, surgical duration, and overall recovery. Poor nutritional status is associated with increased complication rates, prolonged surgery, impaired wound healing, and higher perioperative mortality. Both high and low BMI negatively impact surgical outcomes. Obesity is linked to protracted surgery and increased blood loss, while underweight patients have higher perioperative mortality. Optimizing perioperative nutrition is important for improving surgical outcomes in HNC patients. A multidisciplinary approach is necessary to tailor nutritional support and enhance recovery. Further research should focus on long-term weight management strategies and identifying biomarkers predictive of surgical success.
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Registered trials
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