Evidence map›Paper›PMID 40507336›Full record

ReviewCancers2025

Beneficial Outcomes of Immunoenhancing Nutritional Interventions in Perioperative Care for Oral Cancer: A Systematic Review and Meta-Analysis.

Shin-Ichiro Hiraoka, Takahiro Abe, Masahiro Watanabe, Daisuke Takeda, Hidemichi Yuasa, Masatoshi Adachi, Narikazu Uzawa, Hiroshi Kurita

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shin-Ichiro HiraokaThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.ORCID 0000-0002-0018-9523
Takahiro AbeThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.
Masahiro WatanabeThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.
Daisuke TakedaThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.ORCID 0009-0000-5878-8871
Hidemichi YuasaThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.
Masatoshi AdachiThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.
Narikazu UzawaThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.
Hiroshi KuritaThe Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan.

Funding

The Japanese Society of Oral and Maxillofacial Surgeons No number has been assigned.
6 · The paper itself

Abstract

backgroundThis systematic review aimed to evaluate the efficacy of immunoenhancing nutritional therapy compared to conventional nutritional care in reducing perioperative complications in adult patients undergoing surgery for oral cancer. Given the unclear role of immunonutrition in this specific surgical setting, we synthesized available randomized controlled trials to assess outcomes such as surgical site infections, wound healing complications, hospital stay, and adverse events.

methodsPatients who underwent planned oral cancer surgery were included. The intervention group received oral or enteral immunoenhancing nutritional agents preoperatively, postoperatively, or both, while the control group received standard care (intravenous fluids) and/or macromolecular nutritional supplements. PubMed, Cochrane CENTRAL, and Central Medical Journal were comprehensively searched for randomized controlled trials (RCTs); eight RCTs were included. The primary outcomes were mortality, suture/healing failure, surgical site infection (SSI), and hospital stay length, with evidence certainty assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.

resultsAlthough mortality estimation was not feasible, hazard ratios from the meta-analysis showed that the intervention significantly improved suture/healing failure, SSI, and hospital stay length. The certainty of evidence was "low" for suture/healing failure and SSI and "moderate" for hospital stay length.

conclusionsPerioperative management with enteral nutritional agents fortified with immunonutrients should be considered in adult patients scheduled for (advanced) oral cancer surgery.

Indexed as

immunonutritionmeta-analysisnutritional supportoral neoplasmsperioperative caresystematic review

Identifiers

PMID40507336
PMCPMC12153621

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.