ArticleCancers2025
Clinical and Morphological Features of ER-Positive HER2-Negative Breast Tumors with PIK3CA Mutations in Russian Patients.
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Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Who cites it
1 citing paper in PubMed.
- Tumor Mutational Landscape and Its Correlation With Histopathological Characteristics in Breast Cancer.Cancer genomics & proteomicsArticle
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Authors and funding
88 authors.
Tatyana N SokolovaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Grigory A YanusNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.ORCID 0000-0002-9844-4536
Svetlana N AleksakhinaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Yana V BelyshevaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Aleksandra P ChernyakovaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Yulia S ZharnakovaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Alisa S NikitinaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.ORCID 0009-0008-9860-0771
Tatyana M StebnevaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Aleksandr S MartianovNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.ORCID 0000-0002-7690-8328
Alla Yu GoryainovaState Budgetary Healthcare Organization "Clinical Oncology Dispensary No.1" of the Ministry of Healthcare of Krasnodar Region, Krasnodar 350040, Russia.
Mark I GluzmanSaint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-8965-8364
Rashida V OrlovaSaint Petersburg State University, Saint Petersburg 199034, Russia.
Anastasiya I Stukan'State Budgetary Healthcare Organization "Clinical Oncology Dispensary No.1" of the Ministry of Healthcare of Krasnodar Region, Krasnodar 350040, Russia.
Alena V ZyuzyukinaFederal State Budgetary Educational Institution of Higher Education "Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University" of MOH of Russia, Krasnoyarsk 660022, Russia.
Ruslan A ZukovState Budgetary Healthcare Institution "Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky", Krasnoyarsk 660113, Russia.
Polina R KorzunSaint-Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.ORCID 0009-0001-5294-5896
Jeyla O BinnatovaSaint-Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.ORCID 0009-0006-8863-1158
Anastasia S AbuzovaSaint-Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia.ORCID 0009-0006-0170-6963
Yulia N MurunovaBudgetary Healthcare Institution of the Khanty-Mansiysk Autonomous District "Surgut Regional Clinical Hospital", Surgut 628408, Russia.
Aleksandr V SultanbaevState Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary" of MOH of the Republic of Bashkortostan, Ufa 450054, Russia.
Elena N VorobevaState Autonomous Healthcare Institution "Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine", Chelyabinsk 454087, Russia.
Leonid M MikhaevichState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Victoria N PylivBudgetary Institution of the Khanty-Mansiysk Autonomous District-Yugra "District Clinical Hospital", Khanty-Mansiysk 628012, Russia.
Anna N LysenkoState Budgetary Healthcare Institution of the Stavropol Region "Stavropol Regional Oncological Center", Stavropol 355047, Russia.
Zarema K KhachmamukState Budgetary Healthcare Organization "Clinical Oncology Dispensary No.1" of the Ministry of Healthcare of Krasnodar Region, Krasnodar 350040, Russia.
Andrey E KozlovState Healthcare Institution "Tula Regional Oncological Dispensary", Tula 300039, Russia.
Sergey Yu BakharevRegional State Budgetary Healthcare Institution "Altai Regional Oncological Dispensary", Barnaul 656045, Russia.
Shagen G ParsyanState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Elena I RossokhaRegional State Budgetary Healthcare Institution "Altai Regional Oncological Dispensary", Barnaul 656045, Russia.
Leri D OsidzeState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Irina S ShumskayaState Autonomous Healthcare Institution of Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Oncological Dispensary", Nizhny Novgorod 603126, Russia.ORCID 0000-0003-4295-1843
Anna V AgaevaState Budgetary Healthcare Institution of the Arkhangelsk Region "Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk 163045, Russia.
Tatyana A KasmyninaRegional State Budgetary Healthcare Institution "Oncological Dispensary", Birobidzhan 679000, Russia.
Veronika V KlimenkoNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.
Kamila T AkhmetgareevaBashkir State Medical University, Ufa 45008, Russia.
Almira A VakhitovaState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Madina D ChakhkievaState Budgetary Institution "Republican Oncological Dispensary named after G.M. Vedzizhev", Plievo, Ingushetia 386124, Russia.
Vadim N DmitrievRegional State Budgetary Healthcare Institution "Belgorod Regional Oncological Dispensary", Belgorod 308010, Russia.
Yana I BakshunRegional State Budgetary Healthcare Institution "Kostroma Clinical Oncological Dispensary", Kostroma 156005, Russia.
Alexey E VasilievState Autonomous Healthcare Institution "Orenburg Regional Clinical Oncological Dispensary", Orenburg 460021, Russia.
Dunya D GasimlyState Budgetary Healthcare Institution "Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky", Krasnoyarsk 660113, Russia.
Nadezhda A KravchenkoState Budgetary Healthcare Institution "Regional Oncological Dispensary", Irkutsk 664044, Russia.
Dmitriy A MaksimovState Budgetary Healthcare Institution "Tver Regional Clinical Oncological Dispensary", Tver 170008, Russia.
Alfia I NesterovaFederal State Autonomous Educational Institution of Higher Education "Kazan (Volga Region) Federal University", Kazan 420008, Russia.ORCID 0000-0003-4249-5518
Ineza O SharvashidzeState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Christina Kh GadzaovaState Budgetary Healthcare Institution "Republican Oncological Dispensary", Vladikavkaz 362002, Russia.
Galina G RakhmankulovaState Budgetary Healthcare Institution of the Arkhangelsk Region "Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk 163045, Russia.ORCID 0009-0000-3529-1862
Zaur M KhamgokovState Budgetary Healthcare Institution of MOH of Kabardino-Balkarian Republic "Republican Oncological Dispensary", Nalchik 360051, Russia.ORCID 0009-0000-2400-5277
Irina K AmirkhanovaBudgetary Healthcare Institution of the Vologda Region "Vologda Regional Oncological Dispensary", Vologda 160012, Russia.
Ludmila V BembeevaState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Vladimir I VladimirovState Budgetary Healthcare Institution of the Stavropol Region "Pyatigorsk Interdistrict Oncological Dispensary", Pyatigorsk 357502, Russia.
Oleg L PetrenkoState Budgetary Healthcare Institution "Regional Clinical Hospital of the Kaliningrad Region", Kaliningrad 236016, Russia.
Natalia G RuskovaRegional State Budgetary Healthcare Institution "Kostroma Clinical Oncological Dispensary", Kostroma 156005, Russia.
Ekaterina L SerikovaState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Ksenia S SubbotinaState Budgetary Healthcare Institution of the Republic of Karelia "Republican Oncological Dispensary", Petrozavodsk 185002, Russia.
Svetlana A TkachenkoState Budgetary Healthcare Institution of the Kaluga Region "Kaluga Regional Clinical Oncological Dispensary", Kaluga 248007, Russia.
Victor L ChangState Budgetary Healthcare Institution "Tambov Regional Oncological Clinical Dispensary", Tambov 392000, Russia.
Sanal P ErdnievState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Victoria S BarbaraState Budgetary Healthcare Institution "Regional Clinical Hospital of the Kaliningrad Region", Kaliningrad 236016, Russia.
Anna V VasilevskayaState Budgetary Healthcare Institution of the Moscow Region "Moscow Regional Oncological Dispensary", Balashikha 143900, Russia.
Yulia V MikheevaSaint Petersburg State Budgetary Healthcare Institution "St. Luke Clinical Hospital", Saint Petersburg 194044, Russia.
Natalia O PopovaTomsk National Research Medical Center of Russian Academy of Sciences, Tomsk 634009, Russia.
Anastasia V FateevaState Budgetary Healthcare Institution "Primorsky Regional Oncological Dispensary", Vladivostok 690105, Russia.
Denis Yu YukalchukState Budgetary Healthcare Institution "Regional Oncological Dispensary", Irkutsk 664044, Russia.
Anna A GrechkinaState Budgetary Healthcare Institution "Primorsky Regional Oncological Dispensary", Vladivostok 690105, Russia.
Khedi S MusayevaState Budgetary Institution "Republican Oncological Dispensary", Grozny 364029, Russia.
Svetlana V OdintsovaEuroCityClinic LLC, Saint Petersburg 197022, Russia.ORCID 0000-0001-5591-7746
Petimat I KhabibulaevaState Budgetary Institution "Republican Oncological Dispensary", Grozny 364029, Russia.
Alina G KhlobystinaState Budgetary Healthcare Institution "City Clinical Oncological Dispensary", Saint Petersburg 197022, Russia.
Kseniya A ShvaikoState Budgetary Healthcare Institution "Volgograd Regional Clinical Oncological Dispensary", Volgograd 400117, Russia.
Elena A BasovaRegional State Budgetary Healthcare Institution "Oncological Dispensary", Birobidzhan 679000, Russia.
Irina A BogomolovaFederal State Budgetary Institution "Federal Scientific Clinical Center for Medical Radiology and Oncology" of FMBA of Russia, Dimitrovgrad 433507, Russia.
Marina B BolievaState Budgetary Healthcare Institution "Republican Oncological Dispensary", Vladikavkaz 362002, Russia.
Viktor E GoldbergTomsk National Research Medical Center of Russian Academy of Sciences, Tomsk 634009, Russia.
Marianna V KibishevaState Budgetary Healthcare Institution of MOH of Kabardino-Balkarian Republic "Republican Oncological Dispensary", Nalchik 360051, Russia.
Konstantin V MenshikovState Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary" of MOH of the Republic of Bashkortostan, Ufa 450054, Russia.
Dmitriy V RyazanovState Budgetary Institution of the Ryazan Region "Regional Clinical Oncological Dispensary", Ryazan 390011, Russia.
Yana A UdalovaTaganrog Branch of the State Budgetary Institution of the Rostov Region "Oncological Dispensary", Taganrog 347910, Russia.
Aleksandr V ShkradyukState Budgetary Healthcare Institution of the Republic of Crimea "Crimean Republican Oncological Clinical Dispensary named after V.M. Efetov", Simferopol 295007, Russia.
Idris M KhabrievState Budgetary Institution "Republican Oncological Dispensary named after G.M. Vedzizhev", Plievo, Ingushetia 386124, Russia.
Dmitriy V KirtbayaState Budgetary Institution of the Krasnodar Region "Oncological Dispensary No.2" of MOH of Krasnodar Region, Sochi 354057, Russia.
Alexey M DegtyarevState Budgetary Institution of the Krasnodar Region "Oncological Dispensary No.2" of MOH of Krasnodar Region, Sochi 354057, Russia.
Aleksandr A EpkhievState Budgetary Healthcare Institution "Republican Oncological Dispensary", Vladikavkaz 362002, Russia.
Yana A TyuginaRegional Budgetary Healthcare Institution "Ivanovo Regional Oncological Dispensary", Ivanovo 153040, Russia.
Mirza A MurachuevState Budgetary Institution of the Republic of Dagestan "Republican Oncology Center", Makhachkala 367000, Russia.
Alena S StelmakhState Budgetary Healthcare Institution "Murmansk Regional Oncology Center", Murmansk 183038, Russia.
Aglaya G IyevlevaNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.ORCID 0000-0001-5454-5186
Evgeny N ImyanitovNational Medical Research Center of Oncology named after N.N. Petrov of MOH of Russia, Saint Petersburg 197758, Russia.ORCID 0000-0003-4529-7891
Funding
Novartis Pharma no number
Abstract
backgroundSeveral targeted drugs have been recently approved for the treatment of
methodsThe tumor material from 1872 patients with ER+/HER2- BC was tested by a combination of PCR-based methods.
resultsMutations were detected in 693/1872 (37%) cases, including 46 BC with two
conclusionsThe results of this study highlight the need to extend the
Indexed as
hormone receptor-positive (HR+)/HER2-negative (HER2−) breast cancermutationPIK3CA
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