Evidence map›Paper›PMID 40507283›Full record

ArticleCancers2025

Socioeconomic Disparities in Breast Cancer Survival: Examining Potential Mediator Role of Oncotype DX(ODX) Test and Stage at Diagnosis Among HR+/HER2- Breast Cancer Women.

Pratibha Shrestha, Qingzhao Yu, Edward S Peters, Edward Trapido, Mei-Chin Hsieh, Tekeda Ferguson, Quyen D Chu, Xiao-Cheng Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pratibha ShresthaDivision of Population Health Sciences, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Qingzhao YuBiostatistics Program, School of Public Health at LSU Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0001-8194-0798
Edward S PetersDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-4928-6532
Edward TrapidoLouisiana Tumor Registry, Epidemiology Program, School of Public Health at LSU Health New Orleans, New Orleans, LA 70112, USA.
Mei-Chin HsiehLouisiana Tumor Registry, Epidemiology Program, School of Public Health at LSU Health New Orleans, New Orleans, LA 70112, USA.ORCID 0000-0001-7842-1225
Tekeda FergusonLouisiana Tumor Registry, Epidemiology Program, School of Public Health at LSU Health New Orleans, New Orleans, LA 70112, USA.
Quyen D ChuSurgical Oncology, Howard University Hospital, Washington, DC 20060, USA.ORCID 0009-0002-4837-5218
Xiao-Cheng WuLouisiana Tumor Registry, Epidemiology Program, School of Public Health at LSU Health New Orleans, New Orleans, LA 70112, USA.ORCID 0000-0003-3663-5027

Funding

Interactions between ES-miRNAs and environmental risk factors are responsible for TNBC progression and associated racial health disparities: a novel analysis with multilevel moderation inferencesR01CA275089 · NCI · LSU HEALTH SCIENCES CENTER · PI Yaguang Xi, Qingzhao Yu · 2023 to 2026
$1.3M
Trends of disparities in breast cancer progression and health care considering multilevel risk factorsR15MD012387 · NIMHD · LSU HEALTH SCIENCES CENTER · PI YU, QINGZHAO · 2017 to 2023
$1.1M
NCI NIH HHS R01 CA275089NIMHD NIH HHS R15 MD012387
6 · The paper itself

Abstract

backgroundWomen with a lower socioeconomic status (SES) have an increased risk of dying from breast cancer (BC) than those with a higher SES. The association of SES with BC survival may be partially mediated by factors such as Oncotype DX (ODX) testing and stage at diagnosis. This study aims to examine SES disparities in survival among HR+/HER2- BC women and to quantify the mediating effects of the ODX test and stage.

methodsWe used data from the Louisiana Tumor Registry to identify women aged 20-90 years diagnosed with stage I-II in 2011-2014 and stage I-III in 2015-2017 HR+/HER2- BC who underwent BC surgery. The follow-up cutoff date was 31 December 2020. Cox proportional hazard regression and generalized mediation analysis were both performed.

resultsOf 8931 BC women, 41.4% underwent ODX testing. After adjusting for sociodemographic, tumor characteristic, and treatment variables, low SES women had a higher hazard of overall death (HR = 1.16, 95% CI: 1.02-1.32) and BC-specific death (HR = 1.37; 95% CI: 1.01-1.87) compared to high SES women. The ODX test and stage explained 9.0% and 11.2% SES differences in the hazard of overall death and 4.4% and 13.3% in BC-specific death, respectively.

conclusionsLow SES is associated with higher hazard rates of overall and cause-specific death among women with breast cancer, even after adjustment. Differences in Oncotype DX (ODX) testing and stage at diagnosis explained part of these disparities. Targeted interventions are needed to improve access to genomic testing and early detection to reduce SES-related disparities in breast cancer outcomes.

Indexed as

breast cancerOncotype DXsocioeconomic statusstagesurvival

Identifiers

PMID40507283
PMCPMC12153767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.