Evidence map›Paper›PMID 40507248›Full record

ArticleCancers2025

Low CD25 in ALK+ Anaplastic Large Cell Lymphoma Is Associated with Older Age, Thrombocytopenia, and Increased Expression of Surface CD3 and CD8.

Shuyu E, L Jeffrey Medeiros, Hong Fang, Shaoying Li, Guilin Tang, Sa A Wang, Wei Wang, C Cameron Yin, M James You, Swaminathan P Iyer and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shuyu EDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0001-6577-8006
Hong FangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0003-1780-5959
Shaoying LiDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0002-6857-0523
Guilin TangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0002-9482-4806
Sa A WangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
Wei WangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
C Cameron YinDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0001-6630-4128
M James YouDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
Swaminathan P IyerDepartment of Lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-1646-813X
Luis MalpicaDepartment of Lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lianqun QiuDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
Zhenya TangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.ORCID 0000-0002-8079-9945
Qing WeiDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
Pei LinDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.
Jie XuDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 72, Houston, TX 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAnaplastic lymphoma kinase (ALK)-positive (+) anaplastic large cell lymphoma (ALCL) is known to express CD25, but its significance has not been well studied.

methodsIn the present study, we identified 54 ALK+ ALCL patients with CD25 results available and investigated the significance of CD25 expression levels.

resultsForty-two (78%) cases had high CD25 expressions, whereas low CD25 expressions were found in 12 (22%) cases. Compared with ALK+ ALCL patients with CD25-high neoplasms, patients with CD25-low neoplasms were older (median: 40 years vs. 29 years,

conclusionsmost cases of ALK+ ALCL highly express CD25 which is a potential target for therapy. ALK+ ALCL with low CD25 expression is associated with older patient age and increased frequency of thrombocytopenia and surface CD3 and CD8 expression.

Indexed as

ALK+ anaplastic large cell lymphomaCD25

Identifiers

PMID40507248
PMCPMC12153566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.