Evidence map›Paper›PMID 40507202›Full record

Trial reportNutrients2025

Effects of a Balanced Diet and Probiotics on Blood Biomarkers and Gut Microbiota in the Elderly: A Community-Based Intervention Study.

Junghyun Park, You-Suk Lee, Do-Kyung Lee, Juyong Hong, Seon-Joo Park, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junghyun ParkDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0003-0762-0168
You-Suk LeeInstitute for Aging and Clinical Nutrition Research, Gachon University, Seongnam 13120, Republic of Korea.
Do-Kyung LeeDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.
Juyong HongDepartment of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0009-0005-3516-1423
Seon-Joo ParkDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0002-1825-1815
Byung Wook LeePharmsville Co., Ltd., Seoul 07793, Republic of Korea.
Sang Min ParkPharmsville Co., Ltd., Seoul 07793, Republic of Korea.
Hae-Jeung LeeDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam 13120, Republic of Korea.ORCID 0000-0001-8353-3619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAging is characterized by dysregulation of the immune system. A balanced diet and probiotic intake can play significant roles in preventing aging-related chronic degenerative diseases and promoting immune function in the elderly. This community-based intervention study investigated the effects of an eight-week intervention involving a balanced diet with or without probiotics on nutritional parameters and gut microbiota composition in Korean elderly individuals.

methodsA total of 48 participants were enrolled and randomly allocated into two groups: 24 received a balanced diet alone, and 24 received a balanced diet combined with probiotics.

resultsThe balanced diet showed beneficial impacts on nutritional and inflammatory biomarkers, including fasting glucose, hemoglobin A1c (HbA1c), albumin, gamma-glutamyl transferase (γ-GT), total cholesterol, high-density lipoprotein cholesterol (HDL-C), immunoglobulin E (IgE), and gut microbiota, such as the

conclusionsOverall, the combination of a balanced diet and probiotics has beneficial effects on nutritional and inflammatory biomarkers as well as gut microbiota composition in elderly individuals. Future meticulously designed randomized controlled trials are required to further understand the health benefits and underlying mechanisms of balanced diets and probiotics in the Korean elderly.

Indexed as

DietGastrointestinal MicrobiomeProbioticsAgedAged, 80 and overBiomarkersBlood GlucoseFemaleGlycated HemoglobinHumansMaleMiddle AgedNutritional StatusRepublic of KoreaBiomarkersBlood GlucoseGlycated Hemoglobinagingbalanced dietbiomarkersgut microbiotaprobiotics

Identifiers

PMID40507202
PMCPMC12158029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.