Evidence map›Paper›PMID 40507145›Full record

ReviewNutrients2025

Dietary Interventions and Oral Nutritional Supplementation in Inflammatory Bowel Disease: Current Evidence and Future Directions.

Brigida Barberio, Luisa Bertin, Sonia Facchin, Erica Bonazzi, Sara Cusano, Giulia Romanelli, Francesco Francini Pesenti, Emanuela Cazzaniga, Paola Palestini, Fabiana Zingone and 1 more

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brigida BarberioDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.
Luisa BertinDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.ORCID 0009-0001-9816-4171
Sonia FacchinDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.ORCID 0000-0002-6774-590X
Erica BonazziDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.
Sara CusanoDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.
Giulia RomanelliClinical Nutrition Unit, Department of Medicine, University of Padua, 35128 Padua, Italy.
Francesco Francini PesentiClinical Nutrition Unit, Department of Medicine, University of Padua, 35128 Padua, Italy.
Emanuela CazzanigaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-5006-2280
Paola PalestiniSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-1045-8838
Fabiana ZingoneDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.ORCID 0000-0003-1133-1502
Edoardo Vincenzo SavarinoDepartment of Surgery, Oncology, Gastroenterology, University of Padua, Via Giustiniani 2, 35121 Padua, Italy.ORCID 0000-0002-3187-2894

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints.

objectivesThis review critically examines the current evidence on dietary strategies and oral nutritional supplementation (ONS) in both Crohn's Disease (CD) and Ulcerative Colitis (UC), highlighting their clinical applications, mechanisms of action, and limitations.

methodsA comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases, analyzing studies on various dietary approaches and ONS in IBD.

resultsExclusive Enteral Nutrition (EEN) is a first-line therapy in pediatric CD, while partial enteral nutrition (PEN) and the Crohn's Disease Exclusion Diet (CDED) show promising efficacy and better adherence in both children and adults. Whole-food-based interventions, including the Mediterranean Diet, Specific Carbohydrate Diet, plant-based diets, and emerging strategies such as CD-TREAT and the Tasty & Healthy diet, have demonstrated varying levels of benefit in disease maintenance and symptom control. Targeted exclusion diets-such as low-FODMAP, low-emulsifier, and low-sulfur diets-may relieve functional symptoms and influence inflammatory activity, although evidence remains preliminary. ONS plays a pivotal role in addressing malnutrition and improving outcomes in perioperative and hospitalized patients.

conclusionsDietary interventions and ONS represent valuable therapeutic tools in IBD management. Future research should prioritize standardized, well-powered clinical trials and personalized nutritional approaches to better define their role within integrated care pathways.

Indexed as

Colitis, UlcerativeCrohn DiseaseDietary SupplementsEnteral NutritionInflammatory Bowel DiseasesChildHumansdietinflammatory bowel diseaseoral nutritional supplementation

Identifiers

PMID40507145
PMCPMC12157630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.