Evidence map›Paper›PMID 40506704›Full record

ArticleJournal of neuroinflammation2025

The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion.

Katharina M Mair, Victoria Guggenberger, Laia Verdú de Juan, Ulrike Köck, Hans Lassmann, Roland S Liblau, Christian G Bien, Jan Bauer

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Reply to "The role of early immunotherapy in Rasmussen's encephalitis".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharina M MairDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria.ORCID http://orcid.org/0000-0003-3339-0714
Victoria GuggenbergerDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria.ORCID http://orcid.org/0009-0007-8029-0405
Laia Verdú de JuanDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria.ORCID http://orcid.org/0000-0003-3173-2768
Ulrike KöckDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria.ORCID http://orcid.org/0009-0002-0831-7638
Hans LassmannDepartment of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria.ORCID http://orcid.org/0000-0001-8617-5052
Roland S LiblauInstitute for Inflammatory and Infectious Diseases, INSERM UMR1291 - CNRS UMR505, Toulouse, France.ORCID http://orcid.org/0000-0001-5477-5475
Christian G Bien *Department of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID http://orcid.org/0000-0003-2225-8654
Jan Bauer *Department of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Vienna, A-1090, Austria. jan.bauer@meduniwien.ac.at.ORCID http://orcid.org/0000-0001-5802-8047

Funding

Austrian Science Fund P34864-B
6 · The paper itself

Abstract

Rasmussen Encephalitis (RE) is a chronic, unilateral epileptic disorder mostly found in children. Neuropathologically, it is characterized by T lymphocyte infiltration targeting neurons and leading to microglia activation, astrogliosis, and cortical degeneration. Within a patient's brain, distinct pathological stages are found that offer a unique opportunity to study T cell dynamics in situ. Using quantitative multiplex fluorescence imaging, we analyzed CD103

Indexed as

BrainEncephalitisMemory T CellsT-LymphocytesAdolescentAntigens, CDChildChild, PreschoolFemaleHumansMaleAntigens, CDImmune checkpoint moleculesNeurodegenerationNeuroinflammationRasmussen encephalitis (RE)Tissue resident memory T cells (TRM)γδ T cells

Identifiers

PMID40506704
PMCPMC12164096

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.