Evidence map›Paper›PMID 40506703›Full record

ArticleMalaria journal2025

Performance of molecular inversion probe DR23K and Paragon MAD

Thomas Katairo, Victor Asua, Bienvenu Nsengimaana, Stephen Tukwasibwe, Francis D Semakuba, Innocent Wiringilimaana, Brian A Kagurusi, Caroline Mwubaha, Jackie Nakasaanya, Shreeya Garg and 13 more

Abstract read
In one paragraph

Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Portable Microhaplotype Object and Tools.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. RecurrentmedRxiv : the preprint server for health sciences · 2025
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Thomas KatairoInfectious Diseases Research Collaboration, Kampala, Uganda.
Victor AsuaInfectious Diseases Research Collaboration, Kampala, Uganda.
Bienvenu NsengimaanaInfectious Diseases Research Collaboration, Kampala, Uganda.
Stephen TukwasibweInfectious Diseases Research Collaboration, Kampala, Uganda.
Francis D SemakubaInfectious Diseases Research Collaboration, Kampala, Uganda.
Innocent WiringilimaanaInfectious Diseases Research Collaboration, Kampala, Uganda.
Brian A KagurusiInfectious Diseases Research Collaboration, Kampala, Uganda.
Caroline MwubahaInfectious Diseases Research Collaboration, Kampala, Uganda.
Jackie NakasaanyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Shreeya GargUniversity of California, San Francisco, CA, USA.
Shahiid KiyagaInfectious Diseases Research Collaboration, Kampala, Uganda.
Monica MbabaziInfectious Diseases Research Collaboration, Kampala, Uganda.
Kisakye D KabbaleInfectious Diseases Research Collaboration, Kampala, Uganda.
Alisen AyitewalaUganda National Health Laboratory Services (UNHLS)/Central Public Health Laboratories (CPHL), Kampala, Uganda.
Samuel L NsobyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Isaac SsewanyanaInfectious Diseases Research Collaboration, Kampala, Uganda.
Jeffrey A BaileyBrown University, Providence, RI, USA.
Andrés Aranda-DíazUniversity of California, San Francisco, CA, USA.
Philip J RosenthalUniversity of California, San Francisco, CA, USA.
Bryan GreenhouseUniversity of California, San Francisco, CA, USA.
Jessica Briggs *University of California, San Francisco, CA, USA. jessica.briggs@ucsf.edu.
Melissa D Conrad *University of California, San Francisco, CA, USA. melissa.conrad@ucsf.edu.

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2010 to 2026
$29.3M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Surveillance to track and characterize antimalarial resistance trends in Ugandan Plasmodium falciparum parasites (STARTUP)R01AI173557 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Melissa D Conrad · 2023 to 2026
$2.9M
Mentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6M
Improving the accuracy of malaria surveillance with serology and parasite genetic dataK23AI166009 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jessica Briggs · 2022 to 2026
$955k
Gates Foundation INV-035751Gates Foundation INV-037316National Institute of Allergy and Infectious Diseases K23AI138496National Institute of Allergy and Infectious Diseases R01AI075045National Institute of Allergy and Infectious Diseases U19AI089674NIAID NIH HHS K23 AI166009NIAID NIH HHS K24 AI144048NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI173557NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

backgroundMolecular surveillance of drug-resistant Plasmodium falciparum is crucial for malaria control in endemic regions. Two targeted-resequencing tools, the Molecular Inversion Probe (MIP) drug resistance panel DR23K and the Multiplexed Amplicons for Drugs, Diagnostics, Diversity, and Differentiation using High-Throughput Targeted Resequencing (MAD

methodsTo compare the performance of DR23K and MAD

resultsAcross the four parasite densities of 10, 100, 1000, and 10,000 parasites/μL, MAD

conclusionsMAD

Indexed as

AntimalarialsDrug ResistanceGenotyping TechniquesHigh-Throughput Nucleotide SequencingMutationPlasmodium falciparumGenotypeHumansMalaria, FalciparumPolymorphism, Single NucleotideUgandaAntimalarialsAntimalarial drug resistanceDR23KMAD4HatTeRMicrohaplotypesMolecular inversion probesPrecisionSensitivitySNPsUganda

Identifiers

PMID40506703
PMCPMC12164144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.