ReviewMicrobial cell factories2025
Establishing Halomonas as a chassis for industrial biotechnology: advances in synthetic biology tool development and metabolic engineering strategies.
Review in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Polyhydroxybutyrate (PHB) production from halophiles: a comprehensive review.Bioresources and bioprocessing · 2026Review
- Understanding Hepatopancreas-Associated Microbiota in the Supralittoral Tylos ponticus (Crustacea, Isopoda, Oniscidea): Insights from Next-Generation Sequencing Approaches.Microbial ecology · 2026Article
- Complete genome sequence ofMicrobiology resource announcements · 2026Article
- COApplied microbiology and biotechnology · 2026Review
- Developing High-Efficiency Electroporation Protocols for Hard-To-Transform Halomonas spp.Microbial biotechnology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundHalomonas species have recently emerged as promising chassis organisms for next-generation industrial biotechnology, due to their ability to thrive under high-salt conditions, where most microorganisms cannot survive. This feature minimizes contamination risks, thus enabling cultivation under open, unsterile conditions. In addition, many Halomonas species naturally produce large amounts of the bioplastic polyhydroxybutyrate and the high-value osmolyte ectoine. MAIN TEXT: This review explores the development of genetic manipulation tools and their pivotal role in establishing the genus Halomonas as an industrial chassis. Key additions to the synthetic biology toolbox, including cloning vectors, genetic parts, and genome editing systems are highlighted, along with challenges faced for their adoption, such as difficulties in transformation. In addition, we showcase how these tools have been employed for the development of more robust, high-producing strains through metabolic engineering, as well as for expanding the portfolio of target metabolites produced by Halomonas.
conclusionRecent developments in synthetic biology tools and metabolic engineering highlighted in this review underscore the potential of Halomonas for large scale metabolite production and provide a promising outlook towards their role as a microbial chassis in industrial biotechnology.
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Registered trials
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