ReviewReproductive sciences (Thousand Oaks, Calif.)2025
Sphingolipids and Male Reproductive Health: A Narrative Review of Their Roles in Spermatogenesis, Fertility, and Dysfunction.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dysregulation of Sphingolipid Metabolism in Non-Obstructive Azoospermia: Insights from Bioinformatics and a Busulfan-Induced Mouse Model.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Article
- Next-Generation Metabolic Reprogramming in iPSC-Derived Cardiomyocytes: CRISPR-EV Synergy for Precision Cardiac Regeneration.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingolipids are bioactive lipids involved in cellular signaling and structural processes. Recent studies highlight their critical role in spermatogenesis, sperm functionality, and male infertility. Key sphingolipid metabolites, such as ceramide, ceramide-1-phosphate, and sphingosine-1-phosphate, mediate signaling pathways related to apoptosis, proliferation, stress responses, necrosis, inflammation, autophagy, aging, and differentiation. This review aims to summarize recent advancements in understanding the roles of sphingolipids in spermatogenesis, sperm motility, capacitation, the acrosome reaction, and fertilization, as well as their impact on abnormal spermatogenesis, gonadal dysfunction, and infertility. A narrative review was conducted by analyzing relevant literature published primarily between 2000 and 2024, focusing on the involvement of sphingolipids in male reproductive physiology. Sphingolipids regulate various stages of spermatogenesis, including germ cell proliferation, differentiation, and apoptosis, while also modulating critical processes such as sperm maturation, membrane remodeling, and signaling during capacitation and the acrosome reaction. Dysregulation of sphingolipid metabolism contributes to abnormal spermatogenesis, oxidative stress, testicular dysfunction, and impaired sperm functionality, which are linked to male infertility. Additionally, sphingolipids are implicated in sperm-oocyte fusion, further underscoring their essential role in male fertility. Understanding the precise mechanisms of sphingolipid action may offer potential therapeutic targets for treating male infertility. Future research should focus on elucidating these mechanisms and exploring interventions to correct sphingolipid imbalances.
Indexed as
Identifiers
40506656What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.