Evidence map›Paper›PMID 40506608›Full record

SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Efficacy of continuous positive airway pressure on atrial fibrillation recurrence after catheter ablation in patients with obstructive sleep apnea: a systematic review and meta-analysis.

Eduardo Dan Itaya, Caique M P Ternes, Timothy Maher, Amanda A D Fernandes, Ana Vitoria Rocha, Catherine Wippel, André Rivera, Andrew H Locke, Andre d'Avila

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eduardo Dan ItayaDepartment of Internal Medicine, University of Connecticut Health, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-5935-8790
Caique M P TernesCardiac Arrhythmia Service, Hospital SOS Cardio, Florianópolis, Brazil.
Timothy MaherHarvard-Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Pilgrim Road, Boston, MA, 02215, USA.
Amanda A D FernandesDepartment of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ana Vitoria RochaDivision of Medicine, Federal University of Goias, Goiania, Brazil.
Catherine WippelDivision of Medicine, Washington University, St. Louis, MO, USA.
André RiveraDepartment of Medicine, Nove de Julho University, São Bernardo Do Campo, Brazil.
Andrew H LockeHarvard-Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Pilgrim Road, Boston, MA, 02215, USA.
Andre d'AvilaCardiac Arrhythmia Service, Hospital SOS Cardio, Florianópolis, Brazil. adavila@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) is associated with an increased risk of atrial fibrillation (AF). However, the impact of continuous positive airway pressure (CPAP) on the recurrence of AF after catheter ablation (CA) in patients with OSA remains unclear.

methodsWe systematically searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) and observational studies comparing CPAP vs. no CPAP use for OSA treatment and recurrence of AF following CA. Heterogeneity was assessed with I

resultsWe included 1 RCT and 10 observational studies with 1536 patients with OSA who underwent CA for AF, of whom 53% used CPAP. Mean follow-up ranged from 3 to 42 months. In the pooled analysis, AF recurrence (OR 0.37; 95% CI 0.23-0.58; p < 0.01) was significantly lower in patients treated with CPAP compared with no CPAP. In the subgroup analysis, the AF recurrence in the CPAP group was also significantly lower after restricting to studies with longer follow-up periods ≥ 18 months (OR 0.28; 95% CI 0.18-0.46; p < 0.01) and in studies with a greater proportion of persistent AF (≥ 50%) (OR 0.31; 95% CI 0.16-0.61; p < 0.01).

conclusionIn patients with OSA and AF who underwent CA, CPAP use was associated with reduced AF recurrence compared to no CPAP use. Most of the data available is derived from observational studies, and the only RCT showed no difference between groups. Thus, results should be interpreted with caution.

Indexed as

Atrial FibrillationCatheter AblationContinuous Positive Airway PressureSleep Apnea, ObstructiveComorbidityFemaleHumansMaleMiddle AgedPrevalenceRecurrenceRisk FactorsTreatment OutcomeAtrial fibrillationContinuous positive airway pressureCPAPObstructive sleep apneaRecurrence

Identifiers

PMID40506608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.