Evidence map›Paper›PMID 40506575›Full record

ReviewMedical oncology (Northwood, London, England)2025

Cancer network pharmacology: multi-network regulatory mechanisms and future directions.

Zixuan Zhao, Jiahan Le, Zhenjie Fu, Shenshen Yang, Yitao Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zixuan Zhao *State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China.
Jiahan Le *School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Zhenjie FuSchool of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Shenshen YangSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China. shine2099@163.com.
Yitao ChenSchool of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China. cytworld@zcmu.edu.cn.

Funding

National Natural Science Foundation of China NO. 82174028
6 · The paper itself

Abstract

Cancer is a medical problem that has been difficult to overcome on a global scale. Owing to the sharing of single or multiple genes or regulatory modules, cancer treatment often faces severe challenges. The core of network pharmacology lies in constructing human disease gene regulation networks and multi-pharmacology network. With the continuous updating and iteration of new technologies, it is helpful for us to systematically understand the occurrence and development mechanism behind complex diseases and elucidate the pharmacological mechanisms from the perspective of biological network balance. This review aims to clarify the application of network pharmacology in exploring the pharmacological treatment mechanism of natural products, drug repositioning, and new technology combinations in the context of complex pathogenesis of cancer, so as to help realize the full potential of network pharmacology. Additionally, we discuss the future development of network pharmacology to guide clinical diagnosis and treatment.

Indexed as

Antineoplastic AgentsGene Regulatory NetworksNeoplasmsNetwork PharmacologyDrug RepositioningHumansAntineoplastic AgentsCancerMolecular mechanismNetwork pharmacologyTraditional Chinese Medicine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.