Evidence map›Paper›PMID 40506571›Full record

ArticleEuropean biophysics journal : EBJ2025

Predictive model for evolving density and viscosity gradients in band-forming ultracentrifugation.

Lukas Dobler, Emre Brookes, Piotr Grodzki, Maciej Lisicki, Borries Demeler, Helmut Cölfen, Piotr Szymczak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European biophysics journal : EBJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lukas DoblerDepartment of Chemistry, Universität Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0002-4249-012X
Emre BrookesDepartment of Chemistry and Biochemistry, University of Montana, Missoula, USA.
Piotr GrodzkiInstitute of Theoretical Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland.
Maciej LisickiInstitute of Theoretical Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0002-6976-0281
Borries DemelerDepartment of Chemistry and Biochemistry, University of Montana, Missoula, USA.ORCID http://orcid.org/0000-0002-2414-9518
Helmut CölfenDepartment of Chemistry, Universität Konstanz, Konstanz, Germany.ORCID http://orcid.org/0000-0002-1148-0308
Piotr SzymczakInstitute of Theoretical Physics, Faculty of Physics, University of Warsaw, Warsaw, Poland. piotrek@fuw.edu.pl.ORCID http://orcid.org/0000-0001-8940-7891

Funding

Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
NIGMS NIH HHS R01 GM120600NIGMS NIH HHS R01GM120600
6 · The paper itself

Abstract

Band-forming experiments allow the study of a wide variety of systems by overlaying two solutions with different densities in an analytical ultracentrifuge. Despite their potential benefits over other methods, these experiments are rarely used because all available fitting software encounters systematic errors, failing to account for the evolving gradient in density and viscosity due to diffusive mixing between the two layers. We develop and experimentally validate a predictive model for the purely diffusive mixing of two solutions in a cylindrical system. Capturing the space- and time-dependent evolution of density and viscosity in band-forming experiments, the model enhances their interpretation and underscores the need for analysis software to account for these dynamic changes.

Indexed as

UltracentrifugationViscosityAnalytical ultracentrifugationBand-formingDiffusionDynamic gradientSolvent mixingSolvent properties

Identifiers

PMID40506571
PMCPMC12552396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.