Evidence map›Paper›PMID 40506554›Full record

ArticleCommunications biology2025

The hepatocyte traffic network in the human hepatitis A virus biological cycle from an evolutionary perspective.

Albert Carcereny, Alba Arrebola, Gemma Chavarria-Miró, Montserrat de Castellarnau, Cristina Fuentes, David Garcia-Pedemonte, Adán Martínez-Velázquez, Enric Ribes, Albert Bosch, Susana Guix and 2 more

Abstract read
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In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Albert Carcereny *Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9615-7576
Alba Arrebola *Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1369-9108
Gemma Chavarria-Miró *Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Montserrat de CastellarnauEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Cristina FuentesEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
David Garcia-PedemonteEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Adán Martínez-VelázquezEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Enric RibesEnteric Virus Laboratory, Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain.
Albert BoschEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Susana GuixEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Maria Isabel CostafredaEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain.
Rosa M PintóEnteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, School of Biology, and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain. rpinto@ub.edu.ORCID http://orcid.org/0000-0003-1382-6648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis A virus (HAV) egresses from hepatocytes cloaked in exosomes (eHAV). However, the traffic network used for its release from polarized hepatocytes is not completely understood. We propose that eHAV biogenesis may follow not only an ESCRT-mediated pathway but also the syndecan-syntenin-ALIX pathway. The Bro1 and the V domains of ALIX bind to the pX extension of VP1 and the VP2-late domains of the unmature capsid, respectively. A Serine-to-Glycine replacement at position 134 of VP2, closely located with the first late domain, facilitates the interaction with ALIX promoting the syndecan-syntenin-ALIX pathway and improving the basolateral egress, preferentially using RAB35. This replacement is conserved in hepatoviruses infecting a wide range of mammalian species, but not in hepatoviruses infecting chimpanzees and humans. An inefficient basolateral egress could be a strategy to escape the antiviral cellular response in apes.

Indexed as

Hepatitis AHepatitis A Virus, HumanHepatocytesVirus ReleaseAnimalsBiological EvolutionEvolution, MolecularHumans

Identifiers

PMID40506554
PMCPMC12163080

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.