Evidence map›Paper›PMID 40506518›Full record

ArticleBritish journal of cancer2025

Growth kinetics of high-grade serous ovarian cancer: implications for early detection.

Bharath Narayanan, Thomas Buddenkotte, Hayley Smith, Mitul Shah, Susan Freeman, David Hulse, Gabriel Funingana, Marie-Lyne Alcaraz, Mireia Crispin-Ortuzar, James Brenton and 2 more

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Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bharath NarayananDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3525-4652
Thomas BuddenkotteDepartment of Nuclear Medicine and Interventional Radiology, University Hospital of Hamburg-Eppendorf, Hamburg, Germany.
Hayley SmithDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mitul ShahDepartment of Oncology, University of Cambridge, Cambridge, UK.
Susan FreemanDepartment of Radiology, Addenbrooke's Hospital, Cambridge, UK.
David HulseDepartment of Radiology, Addenbrooke's Hospital, Cambridge, UK.
Gabriel FuninganaDepartment of Oncology, University of Cambridge, Cambridge, UK.
Marie-Lyne AlcarazDepartment of Oncology, University of Cambridge, Cambridge, UK.
Mireia Crispin-OrtuzarEarly Cancer Institute, University of Cambridge, Cambridge, UK.
James BrentonDepartment of Oncology, University of Cambridge, Cambridge, UK.
Paul PharoahCedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8494-732X
Nora PashayanDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK. np275@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0003-0843-2468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological cancer with patients routinely diagnosed at advanced stages. Evidence from randomized controlled trials indicates that annual screening may not reduce cancer-related deaths. We aim to characterise the growth kinetics of HGSOC to understand why early detection failed and under what conditions it might prove fruitful.

methodsWe analysed data from 597 HGSOC patients and identified 34 cases with serial CT scans. We calculated the growth rates of lesions in the ovaries/pelvis and the omentum and estimated the time to metastasis using a Gompertz model. Finally, we simulated ultrasound and CA125 based screening in a virtual population of patients.

resultsGrowing lesions in the ovaries and the omentum doubled in volume every 2.2 months and 1.8 months respectively. The 11 cases with growing lesions in both sites had a median interval of 13.1 months between disease initiation and the onset of metastasis. Our simulations suggested that 27% of tumours would metastasise before screen detection. The remainder would provide a median window of 4.2 months for detection before metastasis.

conclusionOur results suggest that HGSOC lesions have short times to metastasis, preventing effective early detection using current screening approaches.

Indexed as

Cystadenocarcinoma, SerousEarly Detection of CancerOvarian NeoplasmsAdultAgedCA-125 AntigenFemaleHumansKineticsMiddle AgedNeoplasm GradingOmentumTomography, X-Ray ComputedCA-125 Antigen

Identifiers

PMID40506518
PMCPMC12356848

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.