Evidence map›Paper›PMID 40506516›Full record

ArticleBritish journal of cancer2025

Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence.

Ines Mesa-Eguiagaray, Andrii Iakovliev, Xue Li, Maria Timofeeva, Yazhou He, Xiaomeng Zhang, Farhat V N Din, Susan M Farrington, Athina Spiliopoulou, Malcolm G Dunlop and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ines Mesa-EguiagarayCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. ieguiaga@ed.ac.uk.ORCID http://orcid.org/0000-0002-6784-2419
Andrii IakovlievHuman Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Xue LiCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6880-2577
Maria TimofeevaDanish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-2503-4253
Yazhou HeDepartment of Oncology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-2358-0143
Xiaomeng ZhangCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4097-7548
Farhat V N DinColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5466-8282
Susan M FarringtonColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5955-7389
Athina SpiliopoulouHuman Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5929-6585
Malcolm G DunlopColon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3033-5851
Evropi TheodoratouCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5887-9132

Funding

Cancer Research UK (CRUK) C31250/A22804Cancer Research UK (CRUK) C348/A18927Cancer Research UK (CRUK) DRCPGM\100012
6 · The paper itself

Abstract

backgroundEpigenetic changes contribute to colorectal cancer (CRC) pathogenesis. We investigated whether methylation quantitative trait loci (mQTLs) are associated with CRC risk, survival and recurrence.

methodsUsing a well-characterised Scottish case-control study (6821 CRC cases, 14,692 controls), we derived 118,982 mQTLs based on the Genetics of DNA Methylation Consortium (GoDMC). Association analysis between mQTLs and CRC risk, survival and recurrence was performed using logistic regression or Cox models respectively. Additionally, colocalisation analysis was performed.

results19 mQTLs within 10 distinct genomic regions were associated with CRC risk. Two novel regions were mapped to MDGA2 (p value =

conclusionThis study adds to the repertoire of CRC genes. However, we found no associations between methylation and CRC survival or recurrence.

Indexed as

Colorectal NeoplasmsDNA MethylationNeoplasm Recurrence, LocalQuantitative Trait LociAgedCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsScotland

Identifiers

PMID40506516
PMCPMC12356881

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.