Evidence map›Paper›PMID 40506444›Full record

ArticleNPJ Parkinson's disease2025

Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson's disease motor severity.

Theresa Lüth, Amke Caliebe, Carolin Gabbert, Sebastian Sendel, Björn-Hergen Laabs, Inke R König, Christine Klein, Joanne Trinh

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theresa LüthInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Amke CaliebeInstitute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany.
Carolin GabbertInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Sebastian SendelInstitute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany.
Björn-Hergen LaabsInstitute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.
Inke R KönigInstitute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Joanne TrinhInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany. joanne.trinh@uni-luebeck.de.

Funding

Deutsche Forschungsgemeinschaft DFG FOR2488Michael J. Fox Foundation for Parkinson's Research MJFF-019271Michael J. Fox Foundation for Parkinson's Research MJFF-021227
6 · The paper itself

Abstract

Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson's disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects were followed for up to five years. We investigated the association between environmental exposure, lifestyle factors and motor aspect severity over time by applying linear mixed effects models. In LRRK2-PD, black tea consumption was associated with less severe motor aspects (β = -0.51, p = 0.028). In patients with iPD, pesticide exposure was associated with more severe motor aspects over time in PPMI-Online (β = 0.23, p = 3.56 × 10

Identifiers

PMID40506444
PMCPMC12162858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.