ArticleNPJ Parkinson's disease2025
Neural basis of dysexecutive and visuospatial impairments in Parkinson's disease with MCI: a task-based fNIRS study.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Theta tACS Over the Medial Frontal Cortex Modulates Executive Function in Parkinson's Disease: A Randomized, Sham-Controlled Study.CNS neuroscience & therapeutics · 2026Trial
- Dopaminergic- and Cholinergic-Related Structural MRI Patterns Across Cognitive Subtypes of Parkinson's Disease With Mild Cognitive Impairment.European journal of neurology · 2026Article
- Cognitive Impairment Alters Cortical Adaptation and Gait Regulation During Obstacle Walking in Patients With Parkinson's Disease: Evidence From Temporal fNIRS and Gait Dynamics.Journal of movement disorders · 2026Article
- Article
- Visuospatial dysfunction indicates an increased risk of rapid dementia conversion in Parkinson's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Prefrontal cortex activation patterns in age-related cognitive decline: insights from verbal fluency task.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Parkinson's disease with mild cognitive impairment (PD-MCI) includes various cognitive deficits, classified into two subtypes based on the "dual syndrome hypothesis": the executive-dominant dopamine pathway dysfunction impairing executive and language functions (PD-EL subtype), and the visuospatial-dominant non-dopaminergic dysfunction affecting visuospatial perception, attention, and memory (PD-VAM subtype). This study involved 182 participants (122 PD, 60 controls) undergoing cognitive assessments. Using PD-MCI Level II criteria, patients were categorized as PD with normal cognition (PD-NC, 48), PD-EL (34), or PD-VAM (40). Functional near-infrared spectroscopy measured brain activation during verbal fluency (executive) and line orientation (visuospatial) tasks. PD-EL showed lower word accuracy and reduced activation in dorsolateral/ventrolateral prefrontal cortices, supplementary motor area, and orbitofrontal cortex compared to PD-NC. PD-VAM had lower line orientation scores and reduced ventrolateral prefrontal activation. These findings suggest that PD-MCI subtypes may exhibit differential neural activation patterns reflecting their cognitive deficits, underscoring the need for targeted interventions and mechanistic research.
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