Evidence map›Paper›PMID 40506261›Full record

ArticleRenal failure2025

Association between Lyn tyrosine kinase and renal injury in patients with systemic lupus erythematosus.

Jian Sun, Yihong Gu, Wei Lin, Linjuan Luo, Wei Li, Jinrong He, Zishun Zhan, Juan Tang

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PubMed Full text at PMC Publisher
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Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jian SunDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Yihong GuDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Wei LinDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Linjuan LuoDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Wei LiDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Jinrong HeDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Zishun ZhanDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.
Juan TangDepartment of Nephrology and Rheumatology, Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate protein kinase Lyn expression in patients with systemic lupus erythematosus (SLE) or lupus nephritis (LN) and its association with clinical markers.

methodsSixty-one inpatients with SLE were categorized into low SLE Disease Activity Index (SLEDAI) group (SLEDAI < 6,

resultsCompared to the HC group, SLE patients exhibited a decline in both Lyn mRNA and protein expression in PBMCs, with significant downregulation in the high SLEDAI group versus the low SLEDAI group and a notable reduction in the LN group relative to the non-LN group. Lyn levels negatively correlated with SLEDAI and 24-hour urine protein (24h-U-pro) while positively correlated with serum C3, C4, hemoglobin, and albumin. Multiple linear regression indicated an independent association between Lyn mRNA and SLEDAI. ROC curve analysis suggested Lyn as a reliable predictor for SLE, LN, and lupus activity, with histopathological examination revealing that decreased Lyn expression correlated negatively with the renal pathology index (

conclusionsThe protein kinase Lyn was inversely associated with disease activity, albuminuria level and renal pathology activity in SLE and may be a promising biomarker for assessing LN disease activity.

Indexed as

KidneyLupus Erythematosus, SystemicLupus Nephritissrc-Family KinasesAdultBiomarkersBiopsyCase-Control StudiesFemaleHumansLeukocytes, MononuclearMaleMiddle AgedRNA, MessengerSeverity of Illness IndexYoung AdultBiomarkerslyn protein-tyrosine kinaseRNA, Messengersrc-Family Kinaseslupus nephritisProtein kinase Lynrenal pathology indexSLEDAIsystemic lupus erythematosus

Identifiers

PMID40506261
PMCPMC12164392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.