ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025
Translational Potential of Fluorescent PARP1 Inhibitor as a Molecular Contrast Agent for Diagnosis of Basal Cell Carcinoma.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- PARP1 as a biomarker for differentiating melanoma from benign melanocytic lesions.The Journal of investigative dermatology · 2026Article
- PARP-targeted molecular imaging for noninvasive diagnosis and surgical guidance in basal cell carcinoma.American journal of nuclear medicine and molecular imaging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Basal cell carcinoma (BCC), the most common skin cancer, typically requires biopsy for definitive diagnosis. Reflectance confocal microscopy is a noninvasive rule-out test, but the lack of nuclear contrast in BCC often leads to missed diagnoses. Our previous research in ex vivo human skin indicated that PARPi-FL, a poly(adenosine diphosphate ribose) polymerase 1 (PARP1) inhibitor-targeted fluorescent contrast agent, penetrated intact skin when applied topically and improved the diagnosis of BCC compared with reflectance confocal microscopy alone. This study refined PARPi-FL's concentration and application timing to assess its detectability, safety, and feasibility for topical use in clinics and investigated its potential to distinguish BCC from nonmalignant clinical mimickers.
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Registered trials
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